目的:探讨手术切除浅表巨大脂肪瘤的临床疗效。方法:选取2020年1月~2022年12月于我科就诊的16例浅表巨大脂肪瘤患者,男女比例11:5,肩背部10例、臀部4例、颈部2例。超声提示:肿物最大直径10.0~12.5cm,平均11.12 ± 0.38 cm。所有患者均采取局部浸润麻醉下手术切除肿瘤,术中沿设计线切开皮肤、皮下组织,沿瘤体与正常组织间隙完整剥离出肿瘤,术后局部加压包扎、换药、拆线。术后随访1~3年,观察患者切口恢复情况、是否复发等。结果:16例患者脂肪瘤均完整切除,术后伤口无感染,一期愈合,切口恢复良好,5例轻度瘢痕增生,均未见脂肪瘤复发。结论:手术切除是治疗浅表巨大脂肪瘤的有效方法。Objective: To explore the clinical efficacy of surgical excision of superficial giant lipoma. Methods: Sixteen cases of superficial giant lipoma were selected from January 2020 to December 2022, with a male to female ratio of 11:5, 10 cases in the back of the shoulder, 4 cases in the buttocks, and 2 cases in the neck. Ultrasound showed that the maximum diameter of the tumor was 10.0~12.5 cm, and the average diameter was 11.12 ± 0.38 cm. All patients were operated under local infiltration anesthesia to remove the tumors, and the skin and subcutaneous tissues were incised along the design line. The tumors were completely peeled off along the gap between the tumor body and the normal tissues, and the postoperative local compression bandages were used. The dressing was changed and the stitches were removed. After the operation, a local pressure bandage was applied and the dressing was changed and sutures were removed. After the operation, the patients were followed up for 1~3 years to observe the recovery of the incision and whether there was a recurrence of the tumor. Results: All 16 patients had complete resection of lipoma, no postoperative infection, one-stage healing, good recovery of incision, 5 cases with mild keloid hyperplasia, and no recurrence of lipom