搜索到9971篇“ ANTIVIRAL“的相关文章
Natural Products and Antiviral Resistance
2024年
Viral diseases are minacious with the potential for causing pandemics and treatment is complicated because of their inherent ability to mutate and become resistant to drugs. Antiviral drug resistance is a persistent problem that needs continuous attention by scientists, medical professionals, and government agencies. To solve the problem, an in-depth understanding of the intricate interplay between causes of antiviral drug resistance and potential new drugs specifically natural products is imperative in the interest and safety of public health. This review delves into natural product as reservoir for antiviral agents with the peculiar potentials for addressing the complexities associated with multi-drug resistant and emerging viral strains. An evaluation of the mechanisms underlying antiviral drug activity, antiviral drug resistance is addressed, with emphasis on production of broad-spectrum antiviral agents from natural sources. There is a need for continued natural product-based research, identification of new species and novel compounds.
Erute Magdalene AdongbedeJanak Raj KhatiwadaRishipal Rastrapal BansodeLeonard Lamont Williams
关键词:PHYTOCHEMICALS
Black Garlic as an Antiviral for Herpes Simplex Virus-2 in Lung Cells
2024年
Allicin, an antioxidant, is known for providing garlic with its unique fragrance and taste, as well as for its antimicrobial properties. Black garlic, a fermented form of garlic, contains higher levels of antioxidants than fresh garlic. Antioxidants play a vital role in alleviating cellular stress during viral infections. Viral infections result in oxidative stress through the production of reactive oxidative species (ROS). A prolonged state of oxidative stress can result in cell death, DNA damage, and disease progression. In this study, black garlic extract (BGE) is evaluated for its ability to mitigate cytopathic effects and oxidative stress caused by herpes simplex virus-2 (HSV-2) infections in vitro. Antiviral assays were performed to determine the percent of viral inhibition resulting from treatment with the BGE. ROS-GloTM H2O2 assays were then completed to measure the post-infection ROS levels of BGE-treated virus and cells. The results thus far suggest that BGE may inhibit viral infection and decrease levels of oxidative stress.
Jenna R. HorowitzLee H. LeeSandra D. Adams
关键词:ANTIOXIDANTANTIVIRALALLICIN
无机纳米抗病毒材料及其抗病毒性检测技术的研究进展
2024年
病毒感染是人类面临严峻的健康挑战,COVID-19大流行的形势下增加了对抗病毒特性材料的需求,尤其是在公共场所。本文从病毒的形态、特征以及生命周期过程等探讨抗病毒材料的设计原则,综述了近年来几种研究广泛的金属与金属化合物、光响应型半导体、石墨烯、复合材料等无机纳米抗病毒材料,并对其抗病毒性能与抗病毒机制进行了总结与讨论,总结了无机纳米材料表面病毒活性的检测方法与相关制品的标准化研究现状,并展望了抗病毒材料的开发及其评价技术的发展方向。
刘蕊蕊刘蕊蕊冀志江王静冀志江解帅
关键词:无机纳米材料
广西柳州市HIV感染者早期及时治疗和初始用药方案对抗病毒治疗死亡及脱失的影响
2024年
目的了解HIV感染者早期及时治疗和初始用药方案对抗病毒治疗死亡及脱失的影响,为有效治疗提供依据。方法采用回顾性队列研究方法,从艾滋病防治基本信息系统数据库下载2010—2020年广西柳州市HIV感染者抗病毒治疗数据。采用Cox比例风险回归模型分析死亡和脱失的影响因素。结果共纳入HIV感染者15713例,18~<50岁占53.4%,男性占69.4%,农民占61.0%,治疗前CD4计数<350个/μL占75.1%,总体死亡率4.30/100人年,总体脱失率2.42/100人年。Cox比例风险回归模型分析结果显示,治疗前CD4计数350~<500个/μL(AHR=0.72,95%CI:0.63~0.81)和≥500个/μL(AHR=0.64,95%CI:0.55~0.76),从HIV确证阳性至抗病毒治疗间隔90~<180 d(AHR=1.25,95%CI:1.08~1.45)、180~<365 d(AHR=1.26,95%CI:1.08~1.47)和≥365 d(AHR=1.26,95%CI:1.11~1.44),初始用药方案为D4T+3TC+EFV/NVP(AHR=1.47,95%CI:1.32~1.63)、AZT/D4T/TDF+3TC+LPV/r(AHR=1.73,95%CI:1.50~1.99)与HIV感染者抗病毒治疗死亡有统计学关联(P<0.05);治疗前CD4计数350~<500个/μL(AHR=1.32,95%CI:1.16~1.50)和≥500个/μL(AHR=1.28,95%CI:1.10~1.50),从HIV确证阳性至初始用药间隔≥365 d(AHR=1.21,95%CI:1.04~1.40),初始用药方案为TDF+3TC+NVP(AHR=1.32,95%CI:1.13~1.55)、AZT+3TC+EFV/NVP(AHR=1.43,95%CI:1.26~1.62)、AZT/D4T/TDF+3TC+LPV/r(AHR=1.33,95CI%:1.06~1.67)与HIV感染者抗病毒治疗脱失有统计学关联(P<0.05)。结论HIV感染者早期治疗和及时治疗以及初始用药方案为TDF+3TC+EFV的抗病毒治疗效果好,但需关注治疗前CD4计数高的HIV感染者在抗病毒治疗中面临较高的脱失风险问题。
覃丽泰黄精华陈欢欢蓝光华冯毅邢辉朱金辉蔡文龙阮玉华朱秋映谢艺红
关键词:HIV感染者抗病毒治疗脱失
伊维菌素抗病毒作用及机制研究进展被引量:1
2024年
伊维菌素广泛应用于寄生虫病的防控,近年来,其广谱抗病毒活性受到了学者的关注。本文系统性梳理了伊维菌素抗病毒研究的相关报道,对其针对疱疹病毒、登革热病毒和新型冠状病毒等抗病毒作用及潜在机制进行总结与分析,发现伊维菌素主要是通过干扰病毒复制阶段发挥抗病毒作用,其抗病毒机制可能为抑制病毒编码蛋白与宿主蛋白结合或抑制病毒编码蛋白入核。本文为伊维菌素的抗病毒研究与应用提供参考。
王挺邹振兴胡永灵
关键词:伊维菌素抗病毒活性
抗病毒纺织品的研究现状及其检测标准体系研究
2024年
抗病毒纺织品可以有效抑制病毒的传播,降低交叉感染和再感染的风险。近年来,不同种类的抗病毒材料抗病毒机理得到深入研究。本文介绍了不同种类的抗病毒材料,分析了其抗病毒机理,并讨论了抗病毒纺织品的制备方法及其抗病毒性能的检测标准,展望了抗病毒纺织品的应用前景,为抗病毒纺织品的研究提供了参考。
官杰柳永杰马吉康王肖方伟王莹
Design of antiviral AGO2-dependent short hairpin RNAs
2024年
The increasing emergence and re-emergence of RNA virus outbreaks underlines the urgent need to develop effective antivirals.RNA interference(RNAi)is a sequence-specific gene silencing mechanism that is triggered by small interfering RNAs(siRNAs)or short hairpin RNAs(shRNAs),which exhibits significant promise for antiviral therapy.AGO2-dependent shRNA(agshRNA)generates a single-stranded guide RNA and presents significant advantages over traditional siRNA and shRNA.In this study,we applied a logistic regression algorithm to a previously published chemically siRNA efficacy dataset and built a machine learning-based model with high predictive power.Using this model,we designed siRNA sequences targeting diverse RNA viruses,including human enterovirus A71(EV71),Zika virus(ZIKV),dengue virus 2(DENV2),mouse hepatitis virus(MHV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),and transformed them into agshRNAs.We validated the performance of our agshRNA design by evaluating antiviral efficacies of agshRNAs in cells infected with different viruses.Using the agshRNA targeting EV71 as an example,we showed that the anti-EV71 effect of agshRNA was more potent compared with the corresponding siRNA and shRNA.Moreover,the antiviral effect of agshRNA is dependent on AGO2-processed guide RNA,which can load into the RNA-induced silencing complex(RISC).We also confirmed the antiviral effect of agshRNA in vivo.Together,this work develops a novel antiviral strategy that combines machine learning-based algorithm with agshRNA design to custom design antiviral agshRNAs with high efficiency.
Yuanyuan BieJieling ZhangJiyao ChenYumin ZhangMuhan HuangLeike ZhangXi ZhouYang Qiu
Leveraging Nanotechnology for Addressing COVID-19: Revealing Antiviral Approaches and Hurdles
2024年
The emergence of COVID-19 has caused extensive harm and is recognized as a significant threat to human life worldwide. Currently, the application of nanomedicine techniques in pre-clinical studies related to various infections, such as respiratory viruses, herpes viruses, human papillomavirus, and HIV, has demonstrated success. Nanoparticles, due to their specific attributes, have garnered considerable attention in combating COVID-19. Strategies employing nanomaterials for COVID-19 prevention encompass the development of rapid, precise diagnostic tools, the creation of effective disinfectants, the delivery of mRNA vaccines to the biological system, and the administration of antiretroviral medications within the body. This article focuses on recent research regarding the effectiveness of nano platforms as antiviral measures against coronaviruses. It delves into the molecular characteristics of coronaviruses and the affected target systems, highlighting challenges and limitations in combating SARS-CoV-2. Additionally, it explores potential nanotechnology-based treatments to confront current and future variants of coronaviruses associated with COVID-19 infections.
Mehrnaz MostafaviMahtab Shabani
关键词:CORONAVIRUSNANOMATERIALS
UV,five wavelengths fusion and electrochemical fingerprints combined with antioxidant activity for quality control of antiviral mixture
2024年
Aiming to ensure the consistency of quality control of Traditional Chinese Medicines(TCMs),a combination method of high-performance liquid chromatography(HPLC),ultraviolet(UV),electrochemical(EC)was developed in this study to comprehensively evaluate the quality of Antiviral Mixture(AM),and Comprehensive Linear Quantification Fingerprint Method(CLQFM)was used to process the data.Quantitative analysis of three active substances in TCM was conducted.A fivewavelength fusion fingerprint(FWFF)was developed,using second-order derivatives of UV spectral data to differentiate sample levels effectively.The combination of HPLC and UV spectrophotometry,along with electrochemical fingerprinting(ECFP),successfully evaluated total active substances.Ultimately,a multidimensional profiling analytical system for TCM was developed.
Kaining ZhouZini TangGuoxiang SunPing GuoLili Lan
An optimized high-throughput SARS-CoV-2 dual reporter trans-complementation system for antiviral screening in vitro and in vivo被引量:1
2024年
The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is still epidemic around the world.The manipulation of SARS-CoV-2 is restricted to biosafety level 3 laboratories(BSL-3).In this study,we developed a SARS-CoV-2ΔN-GFP-HiBiT replicon delivery particles(RDPs)encoding a dual reporter gene,GFP-HiBiT,capable of producing both GFP signal and luciferase activities.Through optimal selection of the reporter gene,GFP-HiBiT demonstrated superior stability and convenience for antiviral evaluation.Additionally,we established a RDP infection mouse model by delivering the N gene into K18-hACE2 KI mouse through lentivirus.This mouse model supports RDP replication and can be utilized for in vivo antiviral evaluations.In summary,the RDP system serves as a valuable tool for efficient antiviral screening and studying the gene function of SARS-CoV-2.Importantly,this system can be manipulated in BSL-2 laboratories,decreasing the threshold of experimental requirements.
Yingjian LiXue TanJikai DengXuemei LiuQianyun LiuZhen ZhangXiaoya HuangChao ShenKe XuLi ZhouYu Chen
关键词:RDP

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严亚贤
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供职机构:上海交通大学
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谢琪
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陈润生
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供职机构:中国科学院生物物理研究所
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郭威
作品数:124被引量:222H指数:9
供职机构:华中科技大学
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刘志杰
作品数:19被引量:2H指数:1
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