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国家自然科学基金(30570642)

作品数:2 被引量:5H指数:2
相关作者:刘晓蓉邓宇虹廖卫平秦兵林绍鹏更多>>
相关机构:广州医学院第二附属医院更多>>
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Immunohistochemical investigation of voltage-gated potassium channel-interacting protein 1 in normal rat brain and Pentylenettrazole-induced seizures被引量:2
2006年
Objective To explore the possible role of voltage-gated potassium channel-interacting protein 1 (KChIP1) in the pathogenesis of epilepsy. Methods Sprague Dawley female adult rats were treated with pentylenettrazole (PTZ) to develop acute and chronic epilepsy models. The approximate coronal sections of normal and epilepsy rat brain were processed for immunohistochemistry. Double-labeling confocal microscopy was used to determine the coexistence of KChIP1 and gamma-aminobutyric acid (GABA). Results KChIP1 was expressed abundantly throughout adult rat brain. KChIP1 is highly co-localize with GABA transmitter in hippocampus and cerebral cortex. In the acute PTZ-induced convulsive rats, the number of KChIP1-postive cells was significantly increased especially in the regions of CA1 and CA3 (P < 0.05); whereas the chronic PTZ-induced convulsive rats were found no changes. The number of GABA-labeled and co-labeled neurons in the hippocampus appeared to have no significant alteration responding to the epilepsy-genesis treatments. Conclusion KChIP1 might be involved in the PTZ-induced epileptogenesis process as a regulator to neuronal excitability through influencing the properties of potassium channels. KChIP1 is preferentially expressed in GABAergic neurons, but its changes did not couple with GABA in the epileptic models.
Tao SUAi-Hua LUOWen-Dong CONGWei-Wen SUNWei-Yi DENGQi-Hua ZHAOZhuo-Hua ZHANGWei-Ping LIAO
关键词:PTZEPILEPSYSEIZUREIMMUNOHISTOCHEMISTRY
双侧脑室旁结节状灰质异位症患者11例影像与临床研究被引量:3
2008年
目的分析双侧脑室旁结节状灰质异位症(BPNH)的影像特征与所致癫癎的临床特点和疗效。方法MRI确诊的BPNH患者11例,根据是否合并其他神经系统解剖异常分为单纯BPNH组和叠加BPNH组,随访1~10年。对照分析2组患者的临床特点和药物治疗长期预后的差异。结果单纯BPNH组患者7例,发病年龄8~32岁,7例患者精神行为智力发育正常,癫癎发作均为部分性发作,4例有异位灰质结节部位的癎样放电,5例有发作间期的颞叶癎样放电,7例患者经卡马西平治疗均有效;叠加BPNH组患者4例,发病年龄3~8个月,均有早期的精神运动发育迟缓,癫癎发作频繁,存在抗癫癎药物抵抗。4例BPNH患者合并有心血管系统畸形。结论单纯BPNH组出现癫癎发作的年龄较叠加BPNH组晚,患者精神行为智力发育正常,发作形式均为部分性发作,对卡马西平治疗敏感,预后好。异位灰质结节部位和颞叶的癎样放电是单纯BPNH组患者的脑电图特征。应注意BPNH患者其他系统疾病的诊断,早期进行治疗。
林绍鹏邓宇虹刘晓蓉常好会秦兵廖卫平
关键词:迷芽瘤水管周灰质磁共振成像
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