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脑铁代谢紊乱引起的神经退行性疾病及其治疗: 神经退行性疾病包括阿尔茨海默病和帕金森病,发病原因及机制仍不完全清楚。虽然大量研究证实这类病人脑铁异常增高,但增高的脑铁是神经元死亡的始因还是后果一直未有定论。脑铁为何异常增高也不明了。明确这些问题对这类疾病临床治疗有极...; 柯亚朱俐钱忠明; 文献传递

呼吸链抑制剂对HepG2细胞DMT1表达量的影响被引量：1: 2006年; 目的:研究缺氧与二价金属离子转运蛋白(d ivalent m etal transporter 1,DMT1)基因表达的关系,观察线粒体有氧呼吸链抑制剂对HepG2细胞DMT1表达量的影响。方法:将呼吸链抑制剂叠氮钠(NaN3)和鱼藤酮(rotenone)分别与HepG2细胞共孵育,用W estern B lot法检测DMT1的表达。结果:10 mmol/L和20 mmol/L的NaN3浓度可明显增加HepG2细胞±IRE DMT1的表达;20μmol/L的Rotenone可明显增加+IRE DMT1的表达,而对-IRE DMT1无明显影响。结论:DMT1的表达受呼吸链的调控,而+IRE DMT1与-IRE DMT1的表达调控可能不完全一样。; 张蕾朱俐; 关键词：叠氮钠鱼藤酮

Ginkgolides promote HIF-1α expression in normoxic PC12 cells: Ginkgo biloba is an ancient Chinese tree and the standardized extract EGb 761 from its leaves has been used in...; ZHU Li, KE Ya, QIAN Zhong-ming ( Institute for Nautical Medicine and Key Laboratory of Neuroregeneration. Nantong University, Nantong 226001, China; 文献传递

发育及DNA损伤反应调节基因1的研究进展被引量：1: 2007年; 发育及DNA损伤反应调节基因1(regulated in development and DNA damage responses 1,REDD1)又称为RTP801,是一个新近发现的低氧诱导因子-1(hypoxia-inducible factor-1,HIF-1)靶基因,在细胞和整体动物缺氧缺血模型中其表达显著升高,随着研究的深入,发现其对多种细胞刺激均能产生应激反应,在细胞凋亡过程中发挥着重要的调节作用;RTP801受到多种细胞信号通路的调控,研究其功能和作用机制可为临床缺血性疾病和肿瘤的防治等提供新的思路。; 吴小梅杜方朱俐; 关键词：低氧诱导因子-1 细胞凋亡

Ginkgolides protect PC12 cells against hypoxia-induced injury by up-regulation of HIF-1a expression and modification and HIF-1 DNA-binding activity via P42/P44(ERK) MAPK pathway: Hypoxia-inducible factor-1 (HIF-1) is a master regulator of cellular and systemic oxygen homeostasis. Under hy...; ZHU Li, KE Ya, QIAN Zhong-ming ( Institute for Nautical Medicine, Nantong University, Nantong 226001, China; 文献传递

Z-Ligustilide protects neuron against forebrain ischemic injury in ICR mice: Radix Angelica Sinensis, known as Danggui among Chinese, has been used to treat cardiovascular and cerebrovasc...; DU Jun-rong, WANG Cheng-yuan, ZHU Li, KE Ya, ZHOU Hua-zhong, GUO Feng-ying, QIAN Zhong-ming ( Laboratory of Iron Metabolism, Department of Applied Biology &?Chemical Technology and National Key Laboratory of Chinese Medicine and Molecular Pharmacology (Shenzhen), Hong Kong Polytechnic University, Hong Kong, China; 文献传递

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国家自然科学基金(30570675)