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国家重点基础研究发展计划(2011CB707701)

作品数:43 被引量:120H指数:5
相关作者:包尚联白净高嵩刘飞张宾更多>>
相关机构:北京大学清华大学加利福尼亚大学更多>>
发文基金:国家重点基础研究发展计划国家自然科学基金北京市自然科学基金更多>>
相关领域:医药卫生自动化与计算机技术理学核科学技术更多>>

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43 条 记 录,以下是 1-10
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A modified interval subdividing based geometric calibration method for interior tomography
2014年
The interior tomography is commonly met in practice, whereas the self-calibration method for geometric parameters remains far from explored. To determine the geometry of interior tomography, a modified interval subdividing based method, which was originally developed by Tan et al.,[11]was presented in this paper. For the self-calibration method, it is necessary to obtain the reconstructed image with only geometric artifacts. Therefore, truncation artifacts reduction is a key problem for the self-calibration method of an interior tomography. In the method, an interior reconstruction algorithm instead of the Feldkamp–Davis–Kress(FDK) algorithm was employed for truncation artifact reduction. Moreover, the concept of a minimum interval was defined as the stop criterion of subdividing to ensure the geometric parameters are determined nicely. The results of numerical simulation demonstrated that our method could provide a solution to the selfcalibration for interior tomography while the original interval subdividing based method could not. Furthermore, real data experiment results showed that our method could significantly suppress geometric artifacts and obtain high quality images for interior tomography with less imaging cost and faster speed compared with the traditional geometric calibration method with a dedicated calibration phantom.
张峰闫镔李磊席晓琦江桦
关键词:断层扫描
体全息成像系统研究进展
2014年
体全息成像系统(VHIS)是以布拉格体全息光栅(VHG)作为关键成像器件的新型成像系统。它利用布拉格体全息光栅严格的波长选择特性和简并性,能够不借助耗时的扫描装置和复杂的重建算法,实现具有高光谱分辨率的连续超光谱成像和具有良好深度分辨率的实时三维多深度成像。首先对体全息成像系统的结构原理进行简要介绍;然后对体全息光栅的制作和复用方式进行详细讲述,对体全息光谱成像系统、复用体全息多维成像系统的功能特性进行了重点介绍;最后对体全息成像系统的特点和发展方向进行了总结。
吕衍路刘飞白净
关键词:体全息光栅
Reduced aliasing artifacts using shaking projection k-space sampling trajectory
2014年
Radial imaging techniques, such as projection-reconstruction(PR), are used in magnetic resonance imaging(MRI)for dynamic imaging, angiography, and short-T2 imaging. They are less sensitive to flow and motion artifacts, and support fast imaging with short echo times. However, aliasing and streaking artifacts are two main sources which degrade radial imaging quality. For a given fixed number of k-space projections, data distributions along radial and angular directions will influence the level of aliasing and streaking artifacts. Conventional radial k-space sampling trajectory introduces an aliasing artifact at the first principal ring of point spread function(PSF). In this paper, a shaking projection(SP) k-space sampling trajectory was proposed to reduce aliasing artifacts in MR images. SP sampling trajectory shifts the projection alternately along the k-space center, which separates k-space data in the azimuthal direction. Simulations based on conventional and SP sampling trajectories were compared with the same number projections. A significant reduction of aliasing artifacts was observed using the SP sampling trajectory. These two trajectories were also compared with different sampling frequencies.A SP trajectory has the same aliasing character when using half sampling frequency(or half data) for reconstruction. SNR comparisons with different white noise levels show that these two trajectories have the same SNR character. In conclusion,the SP trajectory can reduce the aliasing artifact without decreasing SNR and also provide a way for undersampling reconstruction. Furthermore, this method can be applied to three-dimensional(3D) hybrid or spherical radial k-space sampling for a more efficient reduction of aliasing artifacts.
朱艳春杜江杨文超段侪杰王浩宇高嵩包尚联
关键词:运动伪影
并行磁共振成像GRAPPA-SENSE技术被引量:5
2011年
并行磁共振成像技术已在MRI领域被广泛应用。本研究提出一种新的并行成像方法,命名为GRAPPA-SENSE。此法应用GRAPPA(generalized autocalibrating partially parallel acquisitions)算法内插出部分K空间中心未采集数据,生成更为精确的SC-SENSE(self-calibrating sensitivity encoding)重建算法所需的线圈敏感度函数。标准水模实验证明此方法可改善图像质量。
王达包尚联
螺旋断层放疗系统靶损耗状况的监测方法被引量:4
2012年
目的:螺旋断层放疗系统由于其高剂量率、出束时间长和对射线的利用率相对较低等原因,导致它的靶是一个易损耗部件,需要及时更换。同时,换靶的工序复杂耗时,需要合理的安排换靶时机,避免影响患者治疗计划的执行。本文的目标为寻找一种有效且简单的监测靶损耗的方法,以确定及时合理的换靶时机。方法:通过对螺旋断层放疗系统靶相关的文献调研以及实际工作经验总结,发展了一种利用系统自带的监测电离室数据检测靶损耗的名为双电离室剂量率比较法的监测靶损耗的方法。进而,通过对一台螺旋断层放疗系统从2010年3月至2012年1月的追踪监测,每周至少采集一次在空气中的旋转变化程序(Rotational Variation Procedure,简称RUAT)数据,用本文发展的双电离室剂量率比较法对数据进行分析,验证此方法在监测靶的损耗时的有效性。同时,也对厂家推荐的逐脉冲横向剖面曲线变化法的有效性进行了检验。结果:本文发展的双电离室剂量率比较法能监测靶损耗的状况,在靶停转或非常均匀的损耗时,厂家推荐的办法会失效,本文采取的办法依然有效。同时对双电离室剂量率比较法的影响因素进行了分析,并给出了临床换靶的参考条件。结论:本文寻找的双电离室剂量率比较法是一种简单易行、可靠有效的监测靶损耗的方法。
史斌斌包尚联张艺宝张岳
An energy conduction model for cell image segmentation被引量:4
2011年
Cell image segmentation is an essential step in cytopathological analysis.Although their execution speed is fast,the results of cell image segmentation by conventional pixel-based,edge-based and continuity-based methods are often coarse.Fine structures in a cell image can be obtained with a method that quickly adjusts the threshold levels.However,the processing time of such a method is usually long and the final results may be sensitive to intensity differences and other factors.In this article,a new energy model is proposed that synthesizes a differential equation from the conventional and level set methods,and utilizes the nonuniformity property of cell images (e.g.cytoplasms are more uneven than the background).The feasibility and robustness of the proposed model was demonstrated by processing relatively complicated background images of both simulated and real cell images.
MA JingFengBU JiaJunHOU KaiBAO ShangLianCHEN Chun
关键词:细胞图像图像分割水平集方法
医用直线加速器中心轴绝对剂量输出长期稳定性对比分析被引量:24
2016年
目的:分析对比医用直线加速器中心轴光子绝对剂量输出的长期稳定性特点。方法:选取3 台Varian 加速器,以最新IAEA TRS-398 报告中推荐的水中直接剂量法监测15 个月内的剂量输出,用SPSS 和SigmaPlot 软件进行统计分析。结果:在390 条数据中,超过±2%允差有7 次(1.79%)。偏差主要分布在-0.2%~1.2%,最大+2.55%。同一加速器均整模式下不同能量输出稳定性差异显著(P〈0.05),但无临床意义(〈1 cGy 量级)。不同加速器的均整模式输出稳定性显著依赖于机龄(P〈0.05),与机型无关,而非均整模式(FFF)间差异不显著。结论:包括较新的TrueBeam FFF 模式在内的 Varian 加速器中心轴绝对剂量输出的长期稳定性良好,错误率为1%~2%。放疗中心可以晨检仪和标准水箱测量相结合的方法,监测并及时纠正该偏差。
刘卓伦张艺宝岳海振弓健张健胡俏俏蒋璠李莎包尚联吴昊
关键词:医用直线加速器
6MV医用直线电子加速器束流中心方向调整方法的研究被引量:1
2011年
目的:在对6 MV低能电子直线加速器的加速管安装调试过程中,找出一种简单易行的束流调整方法,使束流调整后辐射野的均整度和方形X-辐射野的对称性指标符合国家标准GB15213-94《医用电子加速器性能及试验方法》的要求。方法:经过分析发现束流对称性(SYM)误差产生的原因分为两部分:束流的方向相对于辐射头轴线发生角度Δθ偏离和束流入射位置相对于辐射头轴线发生ΔX偏离,通过试验得到Δθ和ΔX对SYM数值变化的曲线,通过修正加速管连接法兰盘的平行度和同轴度对束流进行调整,并用水箱测量一定深度处辐射野内剂量的均匀性对调整结果进行检查和分析。结果和结论:使用5支加速管进行试验,束流调整前的对称性值在1.0%至2.9%之间,束流调整后的对称性值在0.8%~1.0%之间。达到了束流调整的目地,并且本方法在多台电子直线加速器上使用,结果证明了该方法的有效性和结果的精确性。
李冬青包尚联
关键词:医用电子直线加速器靶点
基于自由形变的3D非线性医学图像配准被引量:3
2011年
目的针对北京大学医学物理和工程北京市重点实验室研发的小动物SPECT/CT成像仪,实现三维上的图像配准以校正成像间产生的组织运动伪影。方法把被成像组织的运动用整体的仿射变换和局部的非线性变换两部分进行表达,并用基于体素的归一化互信息作为配准的相似性测度,建立综合图像相似性测度和空间变换函数平滑性要求的代价方程,用近似牛顿算法(LBFGS)在全空间搜索最优化变换参数使得代价方程取得极值,从而确定该相似性测度下的空间变换函数。结果用模拟数据对该方法进行验证的结果表明,配准后图像间的相关系数值有所增加,误配基本被消除。结论采用此方法能够较好地描述局部组织的非线性运动,消除呼吸运动伪影,实现三维图像的配准。
李文龙程流泉李军包尚联
A Compton scattering image reconstruction algorithm based on total variation minimization
2012年
Compton scattering imaging is a novel radiation imaging method using scattered photons.Its main characteristics are detectors that do not have to be on the opposite side of the source,so avoiding the rotation process.The reconstruction problem of Compton scattering imaging is the inverse problem to solve electron densities from nonlinear equations,which is ill-posed.This means the solution exhibits instability and sensitivity to noise or erroneous measurements.Using the theory for reconstruction of sparse images,a reconstruction algorithm based on total variation minimization is proposed.The reconstruction problem is described as an optimization problem with nonlinear data-consistency constraint.The simulated results show that the proposed algorithm could reduce reconstruction error and improve image quality,especially when there are not enough measurements.
李守鹏王林元闫镔李磊刘拥军
关键词:图像重建最小化总变分非线性方程组成像方法
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