Objective To contrast and analyze the difference of metabolites of intestinal flora between patients with type 2diabetes and normal blood glucose human in Xinjiang Uygur and Kazak.Methods Uygur fecal samples and Kazak fecal samples were collected,and short-chain fatty acids(SCFA)were extracted by water from feces,then the content of SCFA in fecal samples was analyzed by gas-chromatography mass-spectrometry(GC-MS).Results Both Uygurs and Kazaks,in their feces,the content of SCFA in the feces showed significantly decreased in patients with type 2diabetes,and a significant negative linear correlation was shown between the fasting plasma glucose and the concentration of SCFA in the fecal samples.But,there was no statistical differences between uygurs and kazaks,in not only normal blood glucose group,but also type 2 diabetes group.Conclusion The feces of patients with type 2diabetes has an decreased concentration of SCFA.Between Uygurs and Kazaks,the metabolic changes of intestinal flora was similar in patients with type 2diabetes.
WANG YeWANG Chang-huiYU Xin-lanLI GeLIU Jing-baoGAO BingMAO Xin-minLI Lin-lin
Objective To determine the effects of genetic variation in the organic cation transporter 1(OCT1)on the short-term responses of the antidiabetic drug,metformin.Method A total of 22 patients recruited with type 2 diabetes or IFG were treated with metformin(2 000 mg/day)for 1 week.The patients were screened from Second Jikun hospital and Kashidonglu community medicine service,Urumqi,China and their surrounding districts.To examine the effects of metformin on plasma glucose,total cholesterol,low-density lipoprotein-cholesterol,high-density lipoprotein-cholesterol and triglyceride in relation with R61C,G465R and 420 del variants of OCT1(gene encoding organic cation transporter 1,mainly locating in liver,which is metformin's major target)in subjects.In all,R61C,G465R and 420del of OCT1 gene were examined using DNA extracted from whole blood and PCR-RFLP.Data concerning with gene and metformin treatment were handled by t-test.Result After metformin treatment,there were increases both in FPG and LDL(P=0.011and P=0.013 respectively).To divide all participants into mutant and wild groups,according to the polymorphisms of R61C,G465R and 420 del respectively,as well as carriers with one of the mutant genotypes at least and carriers with none of the mutant sites.Analysis was made to compared FPG,Chol,TG,and LDL and HDL between carriers of wild genotypes and carriers of other genotypes showed no statistic significance both before the metformin treatment and after the treatment.The same is the case with changes of FPG,Chol,TG,and LDL and HDL of wild genotype carriers and variant genotype carriers,except of LDL changes(P=0.05)in patients grouped by G465R polymorphisms and TG changes(P=0.03)in subjects differed by 420del genotypes.Conclusion In this study,it is suggested that OCT1 gene polymorphisms have little contribution to the clinical efficacy of blood glucose control by metformin among Uygur people with type 2 diabetes or IFG,but it may have possible relationship with the clinical efficacy on fat metabolism by metformin.
WANG TaoYI Tao-cunWANG YeWANG Zhi-hongWANH Chang-huiMAO Xin-minRAN Xin-jianHU Meng-yinGE Wen-ningZHANG Min-fangXIE Zi-jingLI Shi-qiangLAN YiLI Lin-lin
Objective To investigate the prevalence of diabetes mellitus(T2DM)and related risk factors among uygur adults in Xinjiang.Methods We conducted cross-sectional investigation into detection rate of type 2 diabetes mellitus in Tushala and surrounding areas(including 28 countries and natural villages)by random sampling.Also clinical physical and biological signs of subjects were tested using variance analysis,and risk factors were screened by using multiple factors Logistic regression analysis.Results Rates of detection,realization and treatment for type 2 diabetes mellitus in HeTian were 3.579%,29.412% and 92.308% respectively.Detection rate of hyperlipemia was 63.064%.Statistical significance(P<0.05)was indicated in detection rates of Type 2 diabetes mellitus among uygur adults with different ages and abdominal circumferences(AC).The investigation also showed statistical significance in variable BMI distribution among subjects with different sex and waist-hip ratio(WHR,To compare subjects in Type 2 diabetes mellitus group with people having normal glucose tolerance(NGT)in such levels as age,BMI,TG,Chol,HDL and LDL,it indicated statistical significance(P<0.05).But statistical significance was found in environmental factors.Logistic regression analysis indicated that age,BMI,WHR and AC were risk factors of type 2 diabetes,mellitus,HDL was protection factor of type 2 diabetes,mellitus.Conclusion Detection rate of type 2 diabetes mellitus in Hetian is lower than detection rate of type 2 diabetes mellitus in other parts of Xinjiang,but it beats the average level in nation,while realization rate of T2DM is relatively low.And age,BMI,WHR and AC are risk factors of T2DM,so it suggest that health education should be emphasized,healthy diet should be advocated and prevention,cure for hyperlipemia will be improved.
LIU Xiao-yan LUO Xin WANG Ye WANG Chang-hui Ran Xin-jian MAO Xin-min LI Lin-lin
