Objective:To investigate the therapeutic effects of Jiedu Granules(解毒颗粒),a Chinese medicine(CM) compound,plus Cinobufacini Injection(华蟾素注射液),which was extracted from skin of Bufo bufo gargarizans Cantor,to prevent the recurrence of hepatocellular carcinoma(HCC) after surgical resection. Methods:In this case-control trial,a total of 120 patients who stayed in Changhai Hospital were enrolled from December 2001 to December 2006.Sixty patients were treated with Jiedu Granules plus Cinobufacini Injection to prevent tumor recurrence after operation(CM group) and 60 patients were treated with transcatheter arterial chemoembolization(TACE) after operation(TACE group).Progression-free survival(PFS) and overall survival (OS) rates were determined to evaluate the therapeutic effects of post-operative management of patients with HCC.Results:PFS in the CM group was 18.07 months[95%confidence interval(CI):12.49-23.65]and the 1-,2-,3-,4-and 5-year PFS rates were 61%,39%,26%,22%and 12%,respectively.PFS in the TACE group was 8.03 months(95%CI:6.63-9.44) and the 1-,2-,3-,4-and 5-year PFS rates were 34%,11%,7%,2%and 0%,respectively.There was significant difference in survival rate between the two groups(P<0.01).The mean survival time(MST) of patients in the CM group was 49.53 months versus 39.90 months of the TACE group.The 1-,2-,3-,4-and 5-year survival rates were 90%,82%,80%,70%and 63%,respectively,in the CM group,and 79%,70%,60%,60%and 36%,respectively,in the TACE group.There was significant difference in survival time between the two groups(P=0.045).Conclusions:Jiedu Granules plus Cinobufacini Injection,a combination that is commonly used for post-operation management of HCC,can postpone tumor recurrence and metastasis, prolong the survival time and increase the survival rate of post-surgical patients with HCC.However,these findings need to be confirmed in a prospective,randomized controlled trial.
OBJECTIVE:To compare the long-term effectiveness of compound Ruanjianhugan(RJH)tablets and interventional therapy(IT) in patients after resection of small hepatocellular carcinoma(HCC).METHODS:A retrospective study was conducted in 399 patients after resection of small HCC who were admitted between January 1987 and December 2008 in the Department of Hepatobiliary Surgery and Center of Minimlly Invasive Surgery,First Affiliated Hospital of Guangxi Medical University.Four groups were based on different therapy modes:a TCM-only(TCMO) group,a TCM combined with interventional therapy(TCM-IT) group,an interventional therapy-only(ITO) group,and a simple operation(SO) group.Prognostic factors were correlated with overall survival(OS) and OS rates were calculated with the Kaplan-Meier method,and multivariate analyses for factors affecting survival were evaluated by the Cox proportional hazard model.RESULTS:The median OS was 151.20 months in the TCM-IT group,43.87 months in the ITO group,and 20.77 months in the SO group.All survival rates of the TCMO group were higher than those of the other three groups(>50%).The 5-,10-,and 15-year OS in the TCMO and ITO patients were 83.94%,45.50%,and 71.22% and 33.34%,55.58%,and 9.26%,respectively(risk ratio,0.209;95% confidence interval,0.126-0.347;P=0.000).Multivariate analysis revealed that the independent risk factors were therapy mode(P=0.000),sex(P=0.005),family history(P=0.011),TNM Classification of Malignant Tumor staging(P=0.000),medical care-seeking behavior(P=0.021),and maximum diameter(P=0.030).CONCLUSION:Long-term oral use of compound RJH tablets may improve OS for small HCC after resection compared with IT.
