3-(Diphenylphosphino)propanoic acid(L2) has proved to be an efficient ligand for the copper-catalyzed C–N coupling reactions.N-arylation of imidazoles with aryl iodides catalyzed by CuCl/L2 was smoothly carried out in DMSO at 100 8C with a yield up to 98%.N-arylation of 1H-pyrazole with aryl iodides and bromides catalyzed by Cu(OAc)2/L2 in 1 4-dioxane also gave the corresponding products with yields of40%–98%.
Ya-Shuai LiuYan LiuXiao-Wei MaPing LiuJian-Wei XieBin Dai
Tetrazole-1-acetic acid was found to serve as a superior ligand for CuI-catalyzed N-arylation of imidazoles with aryl iodides under a low catalyst loading(5 mol% of CuI). A variety of aryl iodides could be aminated to provide the N-arylated products in good to excellent yields without the need of an inert atmosphere.
Feng-Tian WuPing LiuXiao-Wei MaJian-Wei XieBin Dai
大力发展非磷配体的钯催化C-C偶联具有重要的理论意义和应用价值。本文设计合成了3个结构稳定、毒性小的卟啉钯配合物,并利用1 H NMR和IR对其结构进行了表征。3个配合物的催化活性结果表明:四(甲氧基苯基)卟啉钯(配合物3,0.1%mol催化剂量)能够在甲苯中有效地催化溴代芳烃与芳基硼酸的Suzuki-Miyaura交叉偶联反应,产率在32%～99%之间,TON值可达到6×104,同时反应过程中没有钯黑析出。
