Refluxing calix[4]-1,3-substituted benzaldehyde derivative(4) with glycine hydrazide derivative,we obtained a novel calix[4]arene hydrazone derivative(5) via'1+2'condensation in a yield of 78%.In the reaction of compound 4 with L-leucine hydrazide derivative at room temperature,lariat calix[4]-1,3-aza-crown(6) with chiral amino acid group as branched chain was synthesized via'1+1'addition in a yield of 70%.The preliminary extraction experiments suggested that hosting compounds 5 and 6 possessed good complexation abilities forα-amino acids.
YANG Fa-fuHUANG Zhi-shengGUO Hong-yuHONG Bi-qiongZHANG Xiao-yi
