Proteins, as the premier building blocks in nature, exhibit extraordinary ability in life activities during which process proteins mostly self-assemble into large complexes to exert prominent functions. Inspired by this, recent chemical and biological studies mainly focus on supramolecular self-assembly of proteins into high ordered architectures, especially the assembly strategy to unravel the formation and function of protein nanostructures. In this review, we summarize the progress made in the engineering of supramolecular protein architectures according to the strategies used to control the orientation and the order of the assembly process. Furthermore, potential applications in biomedical areas of the supramolecular protein nanostructures will also be reviewed.
Redox responsive vesicles were constructed based on guest interaction between fl-cyclodextrin and a ferrocene self-assembly of a supra-amphiphile built by the host- derivative. The structure and destruction-reconstruction reversibility of the "smart" vesicles were clearly characterized by electron microscopy and dynamic light scattering. Notably, these vesicles were proved to be capable of controlled release function and bringing protease resistance to the enzyme, showing great biocompatibility and promising applications.
Tiezheng PanHuixin ZouHongcheng SunYao LiuShengda LiuQuan LuoZeyuan DongJiayun XuJunqiu Liu