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国家教育部博士点基金(20110201120061)

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非小细胞肺癌组织中CXCR4和Nrf2的表达及其临床意义被引量:11
2014年
目的通过检测临床非小细胞肺癌(NSCLC)标本中CXCR4和Nrf2的表达情况,以探究两者在疾病发生发展中的重要作用及相关性,为肺癌诊断和治疗提供新的思路。方法应用免疫组化及Real-time PCR方法对资料统计完整的66例NSCLC标本检测CXCR4及Nrf2的表达情况。结果在NSCLC组织中,CXCR4与Nrf2蛋白及mRNA的表达量均明显高于正常组织(P<0.01)。CXCR4的阳性表达与较大的肿瘤体积(P=0.048)、肿瘤低分化(P=0.024)、较晚的TNM分期(P=0.018)、淋巴转移(P=0.004)及远处转移(P=0.016)相关。Nrf2的阳性表达与较大的肿瘤体积(P=0.008)、较晚的肿瘤TNM分期(P=0.028)、淋巴结转移(P=0.038)与远处转移(P=0.023)相关。进一步发现NSCLC组织中CXCR4与Nrf2的表达呈正相关(r=0.324,P<0.01),且CXCR4、Nrf2共同阳性表达与淋巴结转移及远处转移存在显著相关性。结论证明CXCR4和Nrf2的异常表达与NSCLC的进展、恶性生物学行为密切相关,且二者在NSCLC的发生发展中存在协同作用。
胡婷华姚煜于硕郭卉田涛韩丽丽王文娟郭倩倩王晶南克俊王淑红
关键词:CXCR4非小细胞肺癌生物标记物CXCR4NRF2
Clinicopathologic significance of CXCR4 and Nrf2 in colorectal cancer
2013年
The CXCR4 and Nrf2 signaling pathways are abnormally activated in response to cellular stress in various types of human cancers. In this study, we examined the expression of CXCR4 and Nrf2 in colorectal cancer (CRC) tissue specimens and investigated their correlation with patient clinicopathologic characteristics. We determined CXCR4 and Nrf2 expression in 76 CRC tissue specimens and paired normal tissue specimens by immunohistochemistry and real-time PCR. We found that the protein and mRNA transcript levels of CXCR4 were significantly higher in CRC tissue specimens than in paired normal tissues, while the expressions of Nrf2 protein and mRNA were increased in CRC tissues compared to distant non-cancerous tissues. High expression level of CXCR4 was positively correlated with poorly differentiated (P=0.031), more advanced tumor-node-metastasis (TNM) stage (P=0.019), lymph node metastasis (P=0.007) and distant metastasis (P=0.018). However, the expression of Nrf2 protein was positively correlated with larger tumor size (P=0.049), more advanced TNM stage (P=0.013), lymph node metastasis (P=0.016) and distant metastasis (P=0.023). Moreover, there was a strong relationship between CXCR4 and Nrf2 expression in CRC tissues, indicating that high Nrf2 expression may contribute to CXCR4 overexpression. In addition, combined expression of CXCR4 and Nrf2 strongly correlated with lymph node metastasis and distant metastasis (P=0.003). Furthermore, we found that combined high expression of CXCR4 and Nrf2 had stronger correlation with lymph node metastasis and distant metastasis than any single molecule did. This study indicated that the abnormal expression of CXCR4 and Nrf2 contributed to the progression of CRC.
Tinghua HuYu YaoShuo YuHui GuoLili HanWenjuan WangTao TianYibin HaoZhiyan LiuKejun NanShuhong Wang
关键词:CXCR4NRF2BIOMARKER
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