The insoluble species of Gd ( Ⅲ ) in human blood plasma were investigated by computer simulation. The distribution of the Gd(Ⅲ ) species was obtained. It was found that most of the Gd( Ⅲ ) ions were bound to phosphate to form precipitate GdPO4 at the concentration of 1. 000 10-7 mol/L and when the concentration of the Gd (Ⅲ ) increased to 3. 750 X 10-4 mol/L, in excess of the concentration of phosphate, the Gd ( Ⅲ ) ions were bound to carbonate to form another kind of precipitate, Gd2(CO3)3.
WANG YueLU XingZHANG Hai-yuanYANG Kui-yueNIU Chun-jiNI Jia-zuan
A multi-phase model of Pr(III) speciation in human interstitial fluid was constructed and insoluble Pr(III) speciation was studied. When the total concentration of Pr(III) is below 8.401E-10 mol/L, soluble Pr(III) species are main species. With rising the total concentration of Pr(III), Pr(III) is firstly bound to phosphate to form precipitate of PrPO4, then bound to carbonate and another precipitate of Pr2(CO3)3 was obtained. When the total concentration is between 1.583E-9 mol/L and 4.000E-3 mol/L, the insoluble species are predominant Pr(III) species.
Ca （II） speciation and effect of Gd （III） speciation on Ca （II） speciation in human blood plasma were studied by computer simulation. [CaHCO3]+ is a predominant compound species of Ca （II）. Gd （III） can compete with Ca （II） for biological molecules. The presence of Gd （III） results in a increase of concentration of free Ca （II） and a decrease of concentration of Ca （II） compounds.
Yue WANG, Xing LU, Shu Yun WANG, Jing Fen HAN, Kui Yue YANG, Chun Ji NIU*, Jia Zuan NI Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022
