The sensation of pain is critical for the survival of animals and humans. However, the brain mechanisms underlying pain perception remain largely unknown. How does the brain decode the pain-evoked activity into a particular sensory experience？ Over the past decade, attempts have been made to answer these questions by employing electrophysiological, functional brain imaging, and behavioral approaches, and some basic properties of pain formation have been revealed. Researchers have gradually recognized that there exists a distributed neural network that participates in the transmission and processing of pain information. These studies will further guide the development of more effective treatment for many disorders such as chronic pain.
