Objective To investigate the effect of calcium supplementation on bone mineral density (BMD) in Chinese women with different FokI vitamin D receptor (VDR) genotypes (FF,Ff,and ff) after weaning or resumption of menstruation during lactation.Methods A total of 40 subjects with the same FokI VDR genotype were randomly divided into two groups:one received calcium tablet (600 mg once daily as CaCO 3) and the other placebo tablet once daily for 1 year.At baseline,BMD was measured by dual‐energy X‐ray absorptiometry at lumbar spine (L2‐L4) and at left hip whereas serum PICP,serum OC,and urinary CTX,serum 25(OH)VitD 3,and serum estradiol were measured at weaning and 1 year thereafter.Results After the intervention,BMD at lumbar spine and at left hip increased significantly in all these women with a trend among different FokI VDR genotypes such as FF > Ff > ff (P<0.05,<0.01,and <0.001,respectively).BMD at lumbar spine in women with FF VDR genotype increased much more rapidly than in those with ff VDR genotype (P<0.05).Compared with the control group women with the FF genotype regained more BMD after calcium supplementation (P<0.05).Conclusion Daily calcium 600 mg supplementation has beneficial effect on the bone health of women with FF VDR genotype.
