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组胺对NMDA诱发的神经元兴奋性损伤的保护作用及其机制: 目的在细胞水平探讨组胺及其受体在NMDA诱发的神经元损伤中的作用及其机制。方法采用原代新生大鼠皮层细胞培养的方法,以NMDA急性损伤为模型,观察组胺及H3受体拈抗剂对神经元的作用及机制。结果 NMDA100mM作用3小时...; 戴海斌沈耀胡薇薇范彦英陈忠; 关键词：组胺 CLOBENPROPIT NMDA 神经元; 文献传递

Protective effect of carnosine against NMDA-induced neurotoxicity in differentiated rat PC12 cells: Aim: To investigat the neuroprolective effects of carnosine and its mechanisms of action in an in vitro model ...; Shen Yao Fan Yan - Yin Fan Xiao - Ning Dai Hai - Bin, Fu Qiu - Li Hu Wei - Wei Hu Chen Zhong Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058; 文献传递

Histamine H3 receptor antagonist clobenpropit enhaces GABA release to protect against NMDA -induced excitotoxicity in cultured cortical neurons through the cAMP/PKA pathway: 2006年; Dai Hai-BinFu Qiu-LiShen YaoChen Zhong; 关键词：CLOBENPROPIT 皮质神经元

Protective effect of carnosine against NMDA -induced neurotoxicity in differentiated rat PC12 cells被引量：1: 2006年; Shen Yao Fan Yan -Yin Fan Xiao -Ning Dai Hai- Bin Fu Qiu-Li Hu Wei-Wei Hu ChenZhong; 关键词：肌肽

Mast cell-derived mediators protects PC12 cells against ischemia in vitro: We have previously demonstrated that brain mast cells degranulated under ischemia in in vivo or in vitro exper...; Fan Yan - Yi Shen Yao Fu Qiu - Li Dai Hai - Bin Hu Wei - Wei Chen Zhong Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, China, 310058; 文献传递

Histamine H3 receptor antagonist clobenpropit enhaces GABA release to protect against NMDA-induced excitotoxicity in cultured cortical neurons through the cAMP／PKA pathway: Aim: Using the H3 receptor antagonist clobenpropit, the roles of histamine H3 receptor in NMDA - induced necro...; Dai Hai -Bin Fu Qiu -Li Shen Yao Chen Zhong Department of Pharmacy, Second Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou, 310009; 文献传递

Effect of carnosine on oxygen-glucose deprivation induced degranulation and histamine release of the mast cells: Aim: Carnosine ( β - alanyl - histidine) is a naturally occuring dipeptide that has been characterized as a pu...; Fan Xiao - Ning Shen Yao Fan Yan - Yin Dai Hai - Bin Fu Qiu - Li Hu Wei - Wei Chan Zhong Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, China, 310058; 文献传递

Protective effect of carnosine on amyloid - β42 - induced neurotoxicity in differentiated rat PC12 cells is independent of histamine pathway: 2006年; Fu Qiu-Li Dai Hai-Bin Shen Yao Hu Wei-wei Chen Zhong

Mast cell- derived mediators protects PC12 cells against ischemia in vitro: 2006年; Fan Yan-Yi Shen Yao Fu Qiu-Li Dai Hai-Bin Hu Wei-Wei Chen Zhong; 关键词：PC12细胞

Effect of carnosine on oxygen- glucose deprivation induced degranulation and histamine release of the mast cells: 2006年; Fan Xiao- Ning Shen Yao Fan Yah- Yin Dai Hai- Bin Fu Qiu-Li Hu Wei-Wei Chan Zhong; 关键词：肌肽缺血模型组胺释放

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国家自然科学基金(30600757)