The TBX1 gene is considered to be the most important gene in the aetiology of DiGeorge syndrome (DGS).DGS is a human disorder characterised by a number of phenotypic features involving abnormal development of pharyngeal arches,facial dysmorphogenesis and cardiac outflow tract anomalies.Retinoic acid (RA) deficiency also produces DGS-like phenotypes.The affectd tissues in DGS are derivatives of neural crest cells (NCCs),which originate from the border between the neural plate and non-neural ectoderm,migrate to specific destinations in the body,and generate a variety of derivatives.In our study,we have explored the hypothesis that tbx1 affects NCC development in zebrafish by regulating RA signaling.
WANG WeiZHANG Li-fengGUI Yong-haoHU Jing-yingSONG Hou-yan
