您的位置: 专家智库 > >

国家自然科学基金(30700884)

作品数:3 被引量:23H指数:2
相关作者:高海青邱洁赵韶华张萍曹爱红更多>>
相关机构:山东大学更多>>
发文基金:国家自然科学基金山东省优秀中青年科学家科研奖励基金山东省科技攻关计划更多>>
相关领域:医药卫生生物学水利工程更多>>

文献类型

  • 3篇期刊文章
  • 1篇会议论文

领域

  • 3篇医药卫生
  • 1篇生物学
  • 1篇水利工程

主题

  • 2篇动脉
  • 2篇动脉粥样硬化
  • 2篇OUABAI...
  • 1篇代谢
  • 1篇代谢性
  • 1篇代谢性疾病
  • 1篇代谢综合
  • 1篇代谢综合征
  • 1篇蛋白
  • 1篇蛋白-1
  • 1篇动脉硬化
  • 1篇性疾病
  • 1篇血管
  • 1篇血管内皮
  • 1篇血管内皮功能
  • 1篇血脂
  • 1篇原花青素
  • 1篇他汀
  • 1篇他汀治疗
  • 1篇葡萄籽

机构

  • 2篇山东大学

作者

  • 2篇邱洁
  • 2篇高海青
  • 1篇刘相菊
  • 1篇赵韶华
  • 1篇沈琳
  • 1篇刘勇
  • 1篇曹爱红
  • 1篇张萍

传媒

  • 2篇中华老年医学...
  • 1篇Chines...

年份

  • 1篇2014
  • 2篇2012
  • 1篇2011
3 条 记 录,以下是 1-4
排序方式:
葡萄籽原花青素联合阿托伐他汀治疗老年颈动脉粥样硬化患者的观察被引量:9
2012年
目的观察葡萄籽原花青素和阿托伐他汀联合应用对老年患者颈动脉粥样硬化的疗效。方法将存在颈动脉粥样硬化斑块的老年高脂血症患者122例,随机分为单药组63例,给予阿托伐他汀20mg/d;联合用药组59例,给予阿托伐他汀10mg/d和葡萄多酚胶囊400mg/d。治疗前及治疗后3、6、12个月测定患者平均最大颈动脉内中膜厚度(MMCIMT)、斑块积分、斑块性质及血脂和超敏C反应蛋白(hs—CRP)水平的变化。结果治疗3个月后,单药组和联合用药组患者与治疗前比较血清总胆固醇(TC)[(4.9±1.0)比(6.5±0.7)mmol/L、(4.7士0.6)比(6.3±0.6)mmol/L]、三酰甘油(TG)[(2.3±0.5)比(2.94-_0.4)mmol/L、(2.2±0.7)比(3.0士0.4)mmol/L3、低密度脂蛋白胆固醇(LDL-C)[(3.3士0.9)比(4.2±0.7)mmoi/L、(3.1±0.6)比(4.O±O.6)mmol/L]降低(均P〈0.01),且随着治疗时间的延长进一步降低。联合用药组患者治疗3个月后高密度脂蛋白胆固醇(HDL—C)水平较治疗前升高20.2%(P〈O.05)。治疗后两组患者血清hs—CRP水平均下降(均P〈0.05)。单药组治疗3个月MMCIMT较治疗前减小1.3%(P〉0.05),治疗6个月减小3.4%(P〉0.05),12个月减小5.1%(P〈0.05)。联合用药组治疗3个月后MMCIMT较治疗前减小2.0%(P〉O.05),6个月减小5.3%(P〈0.05),12个月减小8.6%(P〈0.01)。12个月组问比较差异有统计学意义(P〈O.01)。单药组治疗3个月斑块积分较治疗前减小6.8%(P〉O.05),治疗6个月减小14.5%(P〉0.05),12个月减小19.2%(P〈O.05);联合用药组患者治疗3个月斑块积分减少13.1%(P〉O.05),且随着治疗时间的延长,斑块积分进一步降低(6个月下降28.0%,P〈0.05;12个月下降45.0%,P〈0.01)。�
邱洁曹爱红张萍刘勇刘相菊沈琳高海青
关键词:抗氧化剂降血脂药动脉硬化
Proliferating cell nuclear antigen involved in the repair process of ouabain-induced brain damage independent of hypertension in rats
2014年
Background Ouabain is a mammalian adrenocortical hormone that is involved in the pathogenesis of hypertension by inhibiting Na-K ATPase activity.It also participates in a variety of kinase-mediated signaling pathways associated with Na-K ATPase.Previous studies have shown that ouabain can cause cardiac remodeling independent of elevated blood pressure and that proliferating cell nuclear antigen (PCNA) plays a coordinating role for numerous proteins involved in multiple processes associated with DNA synthesis.Therefore,we hypothesized that ouabain might play a role in the cerebral cortex through signaling pathways independent of hypertension.And PCNA might be involved in this process.Methods Male Sprague-Dawley rats were treated with ouabain or with 0.9% nitric sodium as the control group.Systolic blood pressure was recorded weekly.After four weeks of treatment,morphological changes in the cerebral cortex were analyzed using light and transmission electron microscopy.The expression of PCNA in the cerebral cortex was evaluated by immunohistochemistry,real time quantitative PCR,and Western blotting.Results After 4-week treatment,there was no significant difference in systolic blood pressure compared with the control group,but both structural deterioration and up-regulated expression of PCNA in the brain was induced by ouabain treatment.Conclusions These results suggest that ouabain induces alterations in the brain structure,and this effect is independent of blood pressure.PCNA might be involved in the repair process of ouabain-induced brain damage.
You Beian Shen Lin Qiu Jie Liu Xiangju Zhao Shaohua Ji Xiang Wang Yan Gao Haiqing
关键词:OUABAINHYPERTENSION
前纤维蛋白-1对内皮功能影响的研究进展被引量:14
2011年
近年来,血管内皮功能已成为心血管领域研究中发展迅速的热点之一。内皮功能障碍在高血压、心力衰竭、动脉粥样硬化等心血管疾病及糖尿病、代谢综合征等代谢性疾病中发挥着重要的作用。干预血管内皮功能对上述疾病的防治意义重大。
赵韶华高海青邱洁
关键词:血管内皮功能蛋白-1内皮功能障碍动脉粥样硬化代谢性疾病代谢综合征
Effect of ouabain on myocardial ultrastructure and cytoskeleton during the development of ventricular hypertrophy
The aim of this work is to study cytoskeletal impairment during the development of ouabain-induced ventricular...
Shao-hua ZhaoHai-qing GaoXiang JiYan WangXiang-ju LiuBei-an YouXiao-pei CuiJie Qiu
关键词:OUABAINCYTOSKELETONDESMINMYOCARDIUMHYPERTROPHY
文献传递
共1页<1>
聚类工具0