从草苁蓉75%乙醇提取物中分离得到了2个单萜苷类化合物,结合其理化性质,并通过1DNMR(1 H NMR,13 C NMR)及1 H-1 H COSY、HSQC、HMBC、NOESY等多种波谱学方法进行结构鉴定,鉴定2个化合物分别为β-D-glucopyranose 1-(3,7-dimethyl-2-trans-6-octa-dienoate)(化合物1)和6,7-dihydrofoliamenthoic acid diglucoside(化合物2),其中化合物1为新化合物,化合物2为第1次从列当科植物中获得.
Gout is a common of inflammatory arthritis and is caused by the deposition of monosodium urate(MSU)crystals as a result of hyperuricemia(HUA).Although HUA is considered to be the main risk factor for gout,only approximately 10%of the individuals with HUA will eventually experience a gout attack.In this review,we first briefly introduce the development of gout and then summarize several possible reasons for its development.Genetic factors play a more prominent role in gout than in other diseases;functional mutations related to urate control and innate immunity components have been found to be associated with gout.Here,we list some of the most prominent genes involved in the pathogenesis of gout.In joints with MSU deposition,mature macrophages may uptake MSU crystals without causing inflammation,and this helps to maintain joints in an asymptomatic state.As an auxiliary inflammation pathway,the ATP-P2X7R-NLRP3 axis may contribute to the amplification of MSU-induced inflammation to affect the development of gout.Finally,this review summarizes the research progress on natural products that can be used in the treatment of HUA and gout.
Lin LiuDan WangMengyang LiuHaiyang YuQian ChenYuzheng WuRuixia BaoYi ZhangTao Wang
