First, the high-rise building structure design process is divided into three relevant steps, that is, scheme generation and creation, performance evaluation, and scheme optimization. Then with the application of relational database, the case database of high-rise structures is constructed, the structure form-selection designing methods such as the smart algorithm based on CBR, DM, FINS, NN and GA is presented, and the original forms system of this method and its general structure are given. CBR and DM are used to generate scheme candidates; FINS and NN to evaluate and optimize the scheme performance; GA to create new structure forms. Finally, the application cases are presented, whose results fit in with the real project. It proves by combining and using the expert intelligence, algorithm intelligence and machine intelligence that this method makes good use of not only the engineering project knowledge and expertise but also much deeper knowledge contained in various engineering cases. In other words, it is because the form selection has a strong background support of vast real cases that its results prove more reliable and more acceptable. So the introduction of this method provides an effective approach to improving the quality, efficiency, automatic and smart level of high-rise structures form selection design.