国家重点基础研究发展计划(2011CB504400)
- 作品数：5 被引量：11H指数：2
- 相关作者：封洲燕王兆祥余颖胡娜朱玉芳更多>>
- 相关机构：浙江大学浙江农林大学更多>>
- 发文基金：国家重点基础研究发展计划国家自然科学基金更多>>
- 相关领域：医药卫生生物学自动化与计算机技术更多>>
- Characterization of DREAM isoforms in astrocytes and neurons
- Objective Downstream regulatory element antagonist modulator（DREAM）,as a multifunctional Ca binding protein,bi...
- Albert Cheung Hoi YU
- 关键词：ASTROCYTENEURONDREAMISOFORMS
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- 高频电刺激调控脑神经元轴突的仿真研究
- 深部脑刺激（deep brain stimulation，DBS）已经在帕金森病、癫痫病等多种脑神经系统疾病的治疗中展现良好的应用前景。DBS通常使用高频电刺激（high frequency stimulation，HF...
- 郭哲杉
- A new specialization in astrocytes——Glutamate induces nuclear size change through aquaporin 1
- Objective Astrocytes play an important role in the homeostasis of Glu during excitatory information transmissi...
- Albert Cheung Hoi Yu
- 关键词：GLUTAMATEASTROCYTEAQUAPORIN-1
- Neuroglobin associated with protective roles in neurons and astrocytes
- Objective Neuroglobin(Ngb) is a recently discovered globin which is expressed in the brain,retina and other ne...
- Albert Cheung-Hoi YU
- 关键词：NEUROGLOBINCYTOGLOBINASTROCYTESNEURONSPROTECTION
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- AQP5 is differentially regulated in astrocytes during metabolic and traumatic injuries
- Water movement plays vital roles in both physiological and pathological conditions in the brain.Astrocytes are...
- Rui Chao CHAIJiao Hua JIANGAnn Yuen Kwan WONGFeng JIANGKai GAOGreg VATCHERAlbert Cheung Hoi YU
- 关键词：AQUAPORINMCAO
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- 高频电刺激改变神经元锋电位的波形被引量：5
- 2016年
- 为了正确检测和研究高频电刺激（high frequencystimulation,HFS）期间神经元的动作电位发放活动,进而深入揭示深部脑刺激治疗神经系统疾病的机制,本课题研究HFS期间锋电位波形的变化.在麻醉大鼠海马CA1区的输入神经通路Schaffer侧支上,施加1-2 min时长的100或者200 Hz顺向高频刺激（orthodromic-HFS,O-HFS）,利用微电极阵列采集刺激下游神经元的多通道锋电位信号,并获得由O-HFS经过单突触传导激活的中间神经元的单元锋电位波形及其特征参数.结果表明,O-HFS使得锋电位的幅值明显减小而半高宽明显增加,以基线记录为基准计算百分比值,O-HFS期间锋电位的降支幅值和升支幅值分别可减小20%和40%左右,半高宽则增加10%以上.并且,在大量神经元同时产生动作电位期间,或者在比200 Hz具有更大兴奋作用的100 Hz刺激期间,锋电位波形的改变更多,幅值的减小可达50%,宽度的增加可达20%.可以推测,高频电刺激对于神经元的兴奋作用可能升高细胞膜电位,从而改变细胞膜离子通道的活动特性,导致动作电位波形的改变.这些结果支持深部脑刺激具有兴奋性调节作用的假说,对于正确分析高频电刺激期间神经元锋电位活动具有指导意义,也为进一步研究深部脑刺激（DBS）治疗脑神经系统疾病的机制提供了重要线索.
- 朱玉芳封洲燕王兆祥余颖郭哲杉
- 关键词：深部脑刺激幅值群峰电位兴奋性
- AQP1 is involved in glutamate induced nuclear swelling in astrocytes
- Glutamate(Glu),the most important excitatory neurotransmitter in the central nervous systems(CNS),mediates syn...
- Feng JIANGRui Chao CHAIAnn Yuen Kwan WONGChun Zhang YANGYe ZHOUAlbert Cheung Hoi YU
- 关键词：GLUTAMATEASTROCYTE
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- DREAM in astrocyte regulates prodynorphin-dynorphin expression and may take part in chronic pain
- Chronic pain,one of the most ancient and costly health problems,is poorly controlled and its underlying mechan...
- Jiao-Hua JIANGAnn Yuen Kwan WONGJun-Hui WANGFeng-Bo SUNAlbert Cheung Hoi YU
- 关键词：ASTROCYTESDREAMPRODYNORPHINDYNORPHIN
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- Canonical Wnt signaling pathway is involved in astrogliosis via activation of Lrp6
- Mechanical injury of the brain has been studied for decades utilizing in vitro model of astrocytes,regarding t...
- Siqi LIChunzhang YANGZhengping ZHUANGAlbert Cheung Hoi YU
- 关键词：ASTROCYTEBETA-CATENINWNT
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- Aquaporin 1 specifically accumulate around astrocyte nuclear to mediates Glu-induced nuclear swelling
- Objective Aquaporins(AQPs)belong to the water-specific channel protein family and have been reported to involv...
- Albert Cheung Hoi YU
- 关键词：AQUAPORIN-1GLUTAMATEASTROCYTE
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