By analyzing the variability of global SST (sea surface temperature) anomalies, we propose a unified Nifio index using the surface thermal centroid anomaly of the region along the Pacific equator embraced by the 0.7~C contour line of the standard deviation of the SST anomalies and try to unify the traditional Nifio regions into a single entity. The unified Nifio region covers almost all of the traditional Nifio regions. The anomaly time series of the averaged SST over this region are closely correlated to historical Nifio indices. The anomaly time series of the zonal and meridional thermal centroid have close correlation with historical TNI (Trans-Nifio index) indices, showing differences among E1 Nifio (La Nifia) events. The meridional centroid anomaly suggests that areas of maximum temperature anomaly are moving meridionally (although slightly) with synchronous zonal movement. The zonal centroid anomalies of the unified Nifio region are found helpful in the classification of the Eastern Pacific (EP)/Central Pacific (CP) types of E1 Nifio events. More importantly, the zonal centroid anomaly shows that warm areas might move during a single warming/cooling phase. All the current Nifio indices can be well represented by a simple linear combination of unified Nifio indices, which suggests that the thermal anomaly (SSTA) and thermal centroid location anomaly of the unified Nifio region would yield a more complete image of each E1 Nifio/ La Nina event.