With the highly interdisciplinary of research and great development of microfabrication techniques,patterned surfaces have attracted great attention of researchers since they possess specific regularity and orderness of structures.In recent years,series of two dimensional patterned structures have been successfully fabricated,and widely used in anti-reflection,anti-fogging,self-cleaning,and sensing,etc.In the meantime,patterned structures have been gradually used in biologically relative fields such as biomaterials,aiming to deepen the perception of organism and understand the vital movements of human body.In this review,we provide a brief introduction on current status of techniques for two dimensional patterns fabrication,the applications of patterned surfaces in biologically related fields,and give out a prospective on the development of these patterned surfaces in the future.