国家自然科学基金(81172824)
- 作品数：3 被引量：4H指数：2
- 相关作者：夏钰邢飞跃更多>>
- 相关机构：暨南大学更多>>
- 发文基金：国家自然科学基金更多>>
- 相关领域：医药卫生更多>>
- 靶向作用G-四链体DNA的金属配合物的研究进展
- 2013年
- 富含鸟嘌呤(G)碱基DNA能够通过Hoogsteen氢键形成四螺旋结构,该结构被称为G-四链体。诱导端粒DNA形成G-四链体并稳定该结构能起到抑制端粒酶活性,从而达到促进肿瘤细胞凋亡的作用。近年来,G-四链体DNA已成为设计抗肿瘤药物的重要靶点,文章综述铂(Ⅱ)配合物、钌(Ⅱ)配合物、镍(Ⅱ)配合物、铜(Ⅱ)配合物、锌(Ⅱ)配合物及其他金属配合物靶向作用G-四链体DNA的研究进展。
- 夏钰邢飞跃
- 关键词：端粒酶抗肿瘤金属配合物铂钌
- microRNA let-7c is essential for anisomycin-triggered apoptosis of human leukemic cells by linking JNK1/2 to AP-1/STAT1/STAT3 signaling route
- Anisomycin,an antibiotic produced by Streptomyces,strongly induces apoptosis in different histological sorts o...
- Zhiwei ZhouXijian LuJin WangJia XiaoYuhua JiJingfang DiShan ZengJing LiuFeiyue Xing
- 关键词：ANISOMYCINAP-1STAT1STAT3APOPTOSIS
- 文献传递
- E2F2 negatively regulates miRNA let-7c to balance the anisomycin-triggered apoptosis of Jurkat T cells
- Anisomycin is considered as a protein synthesis inhibitor.Our research group has previously found that anisomy...
- Jie HuoJia XiaoYuhua JiYu XiaJingfang DiShan ZengJing LiuFeiyue Xing
- 关键词：ANISOMYCINAPOPTOSIS
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- 颧种植赝复体在上颌骨缺损中的应用被引量：2
- 2020年
- 利用颧种植赝复体修复上颌骨缺损,不仅改善了传统赝复体固位不良的问题,而且又可避免自体组织移植带来的二次创伤和风险。本文从颧种植体植入的解剖学基础、颧种植赝复体的生物力学特征、颧种植体的临床植入、赝复体的设计制作、颧种植赝复体的并发症和存留率等方面进行综述。
- 丘佳玉刘静
- 关键词：颧骨上颌骨存活率生物力学
- Anisomycin alleviates Experimental Autoimmune Encephalolmylitis through the reduction of pro-inflammatory cytokines and Th17 cells, and the inhibition of GFAP and Iba1?
- Experimental autoimmune encephalomyelitis(EAE)is a T cell-mediated autoimmune disease of the central nervous s...
- Manman SunSong LiuYuhua JiJia XiaoJingfang DiShan ZengJing LiuFeiyue Xing
- 关键词：ANISOMYCINGFAPCYTOKINE
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- 后牙种植冠桥修复后邻接触丧失的研究进展被引量：2
- 2018年
- 后牙种植冠桥与天然邻牙之间的邻接触丧失是种植义齿修复后最常见的并发症之一。天然邻牙可发生近中漂移,而种植体无此生理学现象被认为是种植义齿邻接触丧失的主要原因。此外,对颌牙类型、上下颌骨骨密度差异、缺牙修复时间、游离端修复、邻牙骨支持水平等因素均参与引起种植义齿邻接触丧失,而后者可直接造成食物嵌塞、邻牙龋坏、牙周炎种植体周围炎等不良后果。本文从种植义齿修复后邻接触丧失的发生率、种植牙的生物学特性、参与邻接触丧失的因素、邻接触丧失的不良后果及其解决方案等5个方面,对后牙种植冠桥修复后邻接触丧失进行综述。
- 姜慧超刘静
- 关键词：食物嵌塞
- The preparation and characterization of novel TM-loaded selenium nanoparticle SeNPs@TMΔ
- Introduction Selenium nanomaterials and related materials have attracted increased attention for their unique ...
- Yu XiaFangfang XuJia XiaoJingfang DiShan ZengJing liuFeiyue Xing
- Novel TM-loaded selenium nanoparticle SeNPs@TM enhances anticancer efficacy by the activation of cyclin-dependent kinaseinhibiting proteins and apoptotic signaling
- <正>Background:Selenium(Se)nanomaterials have attracted increasing attention for their unique characteristics a...
- Yu XiaPengtao YouJia XiaoYuhua JiXiaoyan WangYi LvZhiwei ZhouSiqi YeChong ZengJingfang DiShan ZengFangfang XuJing liuFeiyue Xing
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