A novel bioinspired phospholipid copolymer was synthesized by the free radical polymerization of poly-2-methacryloyloxyethylphosphorylcholine(MPC), stearyl methacrylate(SMA), hydroxypropyl methacrylate(HPMA) and trimethoxysilylpropyl methacrylate(TSMA). A stable cross-linked coating was obtained via dip-coating, followed by curing at 70 ℃ for 9 h. Contact angle results indicate the coating surface rearrange to get a more hydrophilic surface on the polymer/water interface. The membrane mimic phosphorylcholine coating surface can resist the platelet adhesion and prolong plasma recalcification time significantly. Rhodamine S was used as model drugs to prepare drug-containing coating under the same conditions. Drug-releasing curves fall into Fickian release mechanism and there exists an efficient releasing-amount of the drug until 60 h.
Chitosan as an antibacterial agent and heparin as an anti-adhesive agent were alternatively deposited onto aminolyzed poly(ethylene terephthalate)(PET) to construct anti-adhesive and antibacterial multilayer films.The contact angle and UV data verified the progressive build-up of the multilayer film by alternate deposition of the polyelectrolytes.PRT experiment and in vitro antibacterial assay indicated that the multilayer-modified PET films had much better hemocompatibility and much stronger antibacterial performance than(unmodified) PET.Such an easy processing and shape-independent method to prepare an anti-adhesive and(antibacterial) surface may have a good potential for surface modification of cardiovascular devices.
