Without the non-relativistic approximation in one-loop function, the dominating one-loop contribution to the quark-antiquark potential is studied numerically in terms of perturbative Quantum Chromo Dynamics (QCD). For Coulomb-like potential, the ratio of the one-loop correction to the tree diagram contribution is presented, whose absolute value is about 20%. Our result is consistent with the analysis that the one-loop contribution should be suppressed by a factor αsπ to the leading order contribution. This work can deepen the comprehension of αs in Cornel potential.