Four new tetrahydrofuran lignans,schpropinrins A-D(1-4),together with five known ones,were isolated from the leaves and stems of Schisandra propinqua var.sinensis.Their structures,including absolute configurations,were characterized by means of spectroscopic analysis and ECD calculation.Compounds 1-4 featured a ketal or hemiketal substructure at C-7 and all of the isolates were tested for their anti-HIV integrase activity.
Shan-Zhai SHANGYing-Shan HANYi-Ming SHIXue DUCheng-Qin LIANGMark AWAINBERGZhong-Hua GAOWei-Lie XIAOHan-Dong SUN
Four new indole alkaloids,plasiaticines A-D(1-4),together with two known ones,were isolated from the seeds of Plantago asiatica.The structures of the new compounds were elucidated on the basis of comprehensive analysis of spectroscopic data.All compounds were tested for their cytotoxic activity,and all compounds except 4 were tested for their acetylcholinesterase(AChE)inhibitory activities.
Two new neolignans,manneoinsigins A(1)and B(2),together with four known lignans,were isolated from the leaves and stems of Manglietia insignis.The new compounds were established on the basis of extensive spectroscopic analyses.All compounds except 2 were tested for their cytotoxic activity.Compound 3 showed weak cytotoxic activity against the HL-60 human tumor cell line with the IC50 value of 23.5μM.
Shan-Zhai SHANGJu-Ming YANHai-Bo ZHANGYi-Ming SHIZhong-Hua GAOXue DUYan LIWei-Lie XIAOHan-Dong SUN
Three new highly oxygenated nortriterpenoids,wilsonianadilactones D-F(1-3),were isolated from the leaves and stems of Schisandra wilsoniana.Their structures were established by means of spectroscopic analysis.Compounds 1-3 showed weak anti-HIV-1 activity with the therapeutic index(TI)values(CC50/EC50)greater than 8.16,14.7,and 17.5,respectively.
Guang-Yu YANGYin-Ke LIXing-Jie ZHANGXiao-Nian LILiu-Meng YANGYi-Ming SHIWei-Lie XIAOYong-Tang ZHENGHan-Dong SUN
