A series of bis-quaternary ammonium compounds(bis-QACs) N,N'-hevamethylenebis(1-alkyl-4-carbamoyl pyridinium bromide)(4BCAP-6,n)(alkyl chain length,n=8,10,12,14,16 and 18) were synthesized and characterized.Their surface tensions,critical micelle concentrations(CMC),and antimicrobial activities were evaluated.4BCAP-6,10 exhibited the strongest antimicrobial activities except for that against Proteus vulgari.The activities of 4BCAP-6.n against Escherichia coli zk126 were not significantly influenced by temperature.pH and initial bacteria concentration.These results indicate that bis-QACs exhibit high antimicrobial activity regardless of the environmental conditions.
Xu Zhuo SunNing WangDi CaoZi Yu HuPu MaoHai Bo ZhangXiao Hai Zhou
