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多聚磷酸盐在原核和真核生物中的研究进展被引量：14: 2009年; 多聚磷酸盐(polyphosphate,poly P)广泛存在于自然界无机环境和生命有机体。细菌学研究显示,poly P可增强细胞抵抗外界恶劣环境的能力,促进严瑾反应(strigent response)和孢子形成,促进生物被膜的形成,提高捕食能力,增强细菌毒力等。对真核生物的研究发现,poly P可以促进正常成骨细胞和成纤维细胞分化成熟,参与胞内钙的贮存与释放,刺激一些肿瘤细胞增殖等。本文从现有的信息入手,推测poly P在神经系统中的功能。; 魏峥聂琰晖刘乐庭卢洁于常海; 关键词：多聚磷酸盐中枢神经系统

星形胶质细胞调节性容积减小(RVD)的关键膜蛋白研究进展: 2022年; 星形胶质细胞承担着维持脑部内环境稳态的重要功能,包括维持脑的水电解质平衡。然而,在缺血性脑卒中等多种疾病中,星形胶质细胞会首先出现明显的细胞水肿,进而促进脑水肿的发生,加重脑损伤。调节性容积减小(RVD)是星形胶质细胞面对水肿时快速减小自身部分容积的代偿反应。最新研究进展发现,水通道蛋白(AQP)和体积调节性阴离子通道(VRAC)是RVD过程的关键参与者。VRAC是LRRC8家族成员构成的异多聚体,星形胶质细胞水肿时,VRAC激活,介导阴离子和有机渗透性物质快速向细胞外转运,是RVD的主要驱动力。AQP是一种6次跨膜蛋白,具有选择性的双向水通道,是星形胶质细胞快速水肿的结构基础,同时也是RVD过程中水转移至胞外的“快速通道”。进一步了解VRAC和AQP的结构、功能及其在RVD中发挥的作用,有助于最终解析星形胶质细胞RVD的发生机制并为脑水肿的治疗提供潜在靶点。; 周佐邑高嘉琪高凯龚艳君于常海; 关键词：水通道蛋白星形胶质细胞脑水肿

NDAP is localized in endoplasmic reticulum and related to endoplasmic reticulum stress: ＜正＞Objective Various highly conserved genes and proteins are expressed during embryonic development. Neuronal ...; Albert Cheung Hoi YU; 关键词：DEVELOPMENT CHOP; 文献传递

AQP5 is differentially regulated in astrocytes during metabolic and traumatic injuries: Water movement plays vital roles in both physiological and pathological conditions in the brain.Astrocytes are...; Rui Chao CHAIJiao Hua JIANGAnn Yuen Kwan WONGFeng JIANGKai GAOGreg VATCHERAlbert Cheung Hoi YU; 关键词：AQUAPORIN; 文献传递

AQP1 is involved in glutamate induced nuclear swelling in astrocytes: Glutamate(Glu),the most important excitatory neurotransmitter in the central nervous systems(CNS),mediates syn...; Feng JIANGRui Chao CHAIAnn Yuen Kwan WONGChun Zhang YANGYe ZHOUAlbert Cheung Hoi YU; 关键词：GLUTAMATE ASTROCYTE; 文献传递

DREAM in astrocyte regulates prodynorphin-dynorphin expression and may take part in chronic pain: Chronic pain,one of the most ancient and costly health problems,is poorly controlled and its underlying mechan...; Jiao-Hua JIANGAnn Yuen Kwan WONGJun-Hui WANGFeng-Bo SUNAlbert Cheung Hoi YU; 关键词：ASTROCYTES DREAM PRODYNORPHIN DYNORPHIN; 文献传递

一个功能丰富的转录调控分子——下游调控元件拮抗分子: 下游调控元件拮抗分子(downstream regulatory element antagonist modulator,DREAM)与钙衰蛋白(Calsenilin)和钾通道辅助亚基(potassium channe...; 伏紫冰段旭博李丽娜雷小康蒋烨王晨许寒晓张银连姜交华柴睿超贾熙华于常海; 关键词：DREAM 转录调节疼痛钙信号; 文献传递

A new specialization in astrocytes——Glutamate induces nuclear size change through aquaporin 1: ＜正＞Objective Astrocytes play an important role in the homeostasis of Glu during excitatory information transmi...; Albert Cheung Hoi Yu; 关键词：GLUTAMATE ASTROCYTE AQUAPORIN-1

Canonical Wnt signaling pathway is involved in astrogliosis via activation of Lrp6: Mechanical injury of the brain has been studied for decades utilizing in vitro model of astrocytes,regarding t...; Siqi LIChunzhang YANGZhengping ZHUANGAlbert Cheung Hoi YU; 关键词：ASTROCYTE BETA-CATENIN WNT; 文献传递

Characterization of DREAM isoforms in astrocytes and neurons: Objective Downstream regulatory element antagonist modulator(DREAM),as a multifunctional Ca binding protein,bi...; Albert Cheung Hoi YU; 关键词：ASTROCYTE NEURON DREAM ISOFORMS; 文献传递

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