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腹泻型肠易激综合征发病机制及艾灸治疗概况被引量:6
2011年
从中医学和现代医学的不同角度简要概述了腹泻型肠易激综合征(Irritable Bowel Syndrome,IBS)的发病机制,同时介绍了近年来艾灸治疗腹泻型肠易激综合征的作用原理及临床研究概况,并就目前研究中存在的问题作了述评与思考。
赵继梦施茵赵海音
关键词:肠易激综合征腹泻型发病机制艾灸疗法
Comparison of Electroacupuncture and Mild-Warm Moxibustion on Brain-Gut Function in Patients with Constipation-Predominant Irritable Bowel Syndrome: A Randomized Controlled Trial被引量:26
2018年
Objective: To compare the effects of electroacupuncture (EA) and mild-warm moxibustion (Mox) therapies for constipation-predominant irritable bowel syndrome (C-IBS) patients. Methods: Sixty C-IBS patients were assigned to 2 groups by simple randomized method, i.e. EA group (30 cases) and Mox group (30 cases). Both EA and Mox treatments were performed on bilateral Tianshu (ST 25) and Shangjuxu (ST 37) for 30 min each time, 6 times per week, for 4 consecutive weeks. The gastrointestinal symptoms and psychological symptoms of the two groups were scored before and after treatment. The effects on the corresponding functional brain areas, namely the anterior cingulate cortex (ACC), insular cortex (IC) and prefrontal cortex (PFC) were observed by functional magnetic resonance imaging (fMRI) before and after treatment. Results: Compared with the Mox group, greater improvements in abdominal distension, defecation frequency, difficulty in defecation and stool features were observed in the EA group (all P〈0.01), both Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores were significantly decreased in the EA group (all P〈0.01). Finally, decreased activated voxel values were observed in the ACC, right IC and PFC brain regions of EA group with 150 mL colorectal distension stimulation (P〈0.05 or P〈0.01). Conclusions: Both EA and Mox could significantly improve some of the most intrusive symptoms of C-IBS patients, and EA was more effective than Mox. The therapeutic effect of these two therapies might through modulating of the brain-gut axis function. (Registration No. ChiCTR- TRC-11001349).
ZHAO Ji-meng1LU Jin-hua2YIN Xiao-jun1WU Lu-yi1BAO Chun-hui1CHEN Xing-kui3CHEN Yue-hua4TANG Wei-jun1JIN Xiao-ming6WU Huan-gan1SIll Yin1
关键词:CONSTIPATIONELECTROACUPUNCTUREMOXIBUSTION
Comparative study of electroacupuncture and moxibustion in influencing Tianshu(ST 25) regions mast cells in visceral hyperalgesia rats被引量:1
2016年
Objective:To evaluate and compare electroacupunctures(EA) with different parameters and moxibustion at different temperatures influencing the activation of mast cells(MC) in Tianshu(ST 25) regions of visceral hyperalgesia model rats.Methods:Rats(except for model group) respectively accepted 1 m A or 3 m A EA or moxibustion at 43 or 4 to ℃ ℃stimulate Tianshu(ST 25) points after randomization of the fifty visceral hyperalgesia model rats,and then were compared with that in model and normal groups.Number,degranulation numbers,degranulation rates in Tianshu(ST 25) regions MC of rats in each group were observed using toluidine blue staining.Abdominal withdrawl reflex(AWR) score was used to evaluate the rat visceral hyperalgesia reactions.Results:Compared with the normal group and the model group,MC numbers(P〈0.05,P〈0.01,P〈0.01,P〈0.01),degranulation numbers and degranulation rates(P〈0.01,P〈0.01,P〈0.05,P〈0.01) of Tianshu(ST 25) MC in regions tissues in 43 and 4 moxibustion groups,and 1 m A and 3 m℃ ℃A EA groups all increased significantly.Compared with the model group,AWR scores were significantly lower in 43 and 4 ℃ moxibustion groups,and 1 m A and 3 m℃A EA groups under the stimulation of 20 mm Hg,40 mm Hg,0 mm Hg or 80 mm Hg colorectal distension(CRD)(P〈0.05 in 1 m A and 3 m A EA groups under the stimulation of 20 mm Hg,P〈0.01 in the other groups).AWR scores in 43 ℃and 4 ℃moxibustion groups under the stimulation of 20 mm Hg,40 mm Hg,0 mm Hg or 80 mm Hg CRD were not significantly different from those in the normal group(all P〈0.05);AWR scores in 1 m A EA group under the stimulation of 0 mm Hg or 80 mm Hg were significantly higher than that in the normal group(P〈0.01);AWR score in 3 m A EA group under the stimulation of 0 mm Hg was significantly higher than that in the normal group(P〈0.01),and AWR scores in 3 m A EA group under the stimulation of 20 mm Hg or 80 mm Hg were also higher than that in the normal group�
陈柳赵继梦李雨薇商海霞吴璐一施茵窦传字吴焕淦杨燕萍(译)
关键词:ELECTROACUPUNCTURERATS
电针对腹泻型肠易激综合征患者结肠黏膜5-HT、5-HT3R表达的影响被引量:16
2012年
目的:观察电针对腹泻型肠易激综合征患者结肠黏膜5-HT、5-HT3R表达的影响,探讨其作用机制。方法:分别选取给予电针治疗(选取中脘、天枢、气海等穴,针刺后加电刺激,4周为1个疗程)16例和西药治疗(口服地衣芽孢杆菌和黛力新片)15例的腹泻型IBS患者治疗前后的乙状结肠黏膜组织,采用免疫组化法观察两组患者结肠黏膜5-HT、5-HT3R表达情况。结果:电针组和西药组两组患者治疗前结肠黏膜5-HT、5-HT3R阳性面积和光密度(OD)表达均较正常人有显著性升高(P<0.01,P<0.01);两组患者治疗后均较治疗前有显著性降低(P<0.01,P<0.01),电针组治疗后结肠黏膜5-HT、5-HT3R阳性面积表达则较西药组明显降低,两组间比较差异有统计学意义(P<0.05,P<0.05)。结论:电针可能通过显著降低腹泻型IBS患者结肠黏膜5-HT、5-HT3R表达,进而减弱神经介导的胃肠道运动与分泌,提高内脏痛阈,消除肠道过敏,由此改善胃肠道运动功能状态和内脏高敏感性而达到其治疗之目的。
陈跃华陈兴奎尹小君施茵
关键词:腹泻型肠易激综合征电针5-HT
艾灸调节肠易激综合征脑-肠互动的思路与方法
近年来越来越多的研究研究支持orexin在脑-肠互动过程中可能发挥着重要作用,Orexin与胃肠运动功能紊乱、内脏高敏感性改变密切相关。本文从脑-肠轴与脑-肠互动、orexin、脑-肠互动及IBS三者密切关系、艾灸调节胃...
周志刚吴焕淦施茵
关键词:肠易激综合征艾灸脑-肠互动
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上巨虚穴在针灸治疗肠腑病证中的应用
上巨虚穴作为足阳明胃经要穴、大肠之下合穴,已被广泛用于肠腑病以及肠腑相关病证,大量临床与实验研究均证实其具有良好的效应。本文旨从上巨虚穴治疗肠腑病证的历代认识、临床应用和研究现状等方面给予较详尽的概述,并就目前研究中存在...
施茵吴焕淦张凌凌张榕
关键词:上巨虚针灸疗法
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关于针灸学涉外教学及交流之体会被引量:1
2011年
涉外针灸教学既要按照教学大纲教学,更需要根据各批学生的实际水平,灵活进行针对性教学。加强基本功训练,从细节入手,提高其传统针灸的传承能力。加强中外交流,促进针灸在世界范围内的发展。
赵海音
关键词:针灸教学目标
电针与艾灸对内脏高敏感大鼠穴区辣椒素受体和热休克蛋白70表达的影响及镇痛效应被引量:18
2016年
目的:探讨电针与艾灸对内脏高敏感大鼠穴区辣椒素受体1(VR 1)和热休克蛋白70(HSP 70)表达的影响及其镇痛效应是否存在差异。方法:将SD大鼠随机分为正常组、模型组、艾灸43℃组、艾灸46℃组、电针1mA组、电针3mA组,每组各10只。采取直结肠扩张(CRD)的方法制备内脏高敏感模型。艾灸和电针分别刺激"天枢"穴,每日1次,连续10d。腹部撤回反射(AWR)评分评价大鼠对直肠内不同程度扩张刺激的敏感性,免疫组化法观察穴区VR 1、HSP 70的表达。结果:在20、40、60、80mmHg CRD刺激下,模型组AWR评分均显著升高(P<0.01),艾灸43℃组、艾灸46℃组、电针1mA组、电针3mA组与模型组相比AWR评分均显著降低(P<0.01,P<0.05);艾灸46℃组在40、80mmHg时评分低于电针1mA组(均P<0.05),在40mmHg时评分低于电针3mA组(P<0.05)。模型组穴区VR 1、HSP 70的表达与正常组比较差异无统计学意义(P>0.05);艾灸43℃组、艾灸46℃组穴区VR 1的表达较模型组、电针1mA组、电针3mA组均显著升高(P<0.01),且艾灸46℃组显著高于艾灸43℃组(P<0.01);艾灸43℃组、艾灸46℃组和电针1mA组、电针3mA组穴区HSP 70的表达均较模型组显著升高(P<0.01),其中艾灸46℃组明显高于其他各组(P<0.01)。结论:43℃、46℃不同温度艾灸和1mA、3mA不同强度电针刺激均可不同程度地改善/升高内脏高敏感模型大鼠的痛阈,其中以46℃艾灸的效应最为显著;这种镇痛效应与其能在一定程度上激活穴区VR 1和HSP 70表达有关。
李雨薇赵继梦陈柳商海霞吴璐一包春辉窦传字吴焕淦施茵
关键词:内脏高敏感
电针与益生菌合用黛力新对腹泻型肠易激综合征的疗效比较研究被引量:45
2012年
目的探讨和比较电针与益生菌合用黛力新对腹泻型肠易激综合征(diarrhe atype of irritable bowel syndrome,D-IBS)的临床疗效。方法采用随机数字表法将64例伴有焦虑和(或)抑郁的D-IBS患者随机分成西药组(30例)和电针组(34例),西药组口服益生菌(地衣芽孢杆菌)和黛力新片,电针组予针刺后加电刺激,两组均治疗4周,并随访3个月。观察两组治疗前后消化道症状评分和汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分,以及3个月的随访复发情况。结果西药组总有效率为86.67%,电针组总有效率为88.24%,两组比较,差异无统计学意义(P>0.05)。两组治疗前后消化道症状评分、HAMA和HAMD量表评分组内比较差异均有统计学意义(P<0.05,P<0.01)。两组在排便次数评分和HAMA、HAMD量表评分改善方面比较,差异无统计学意义(P>0.05);腹痛、腹胀评分改善情况电针组优于西药组(P<0.01);粪便形状和黏液便评分改善西药组优于电针组(P<0.01);随访2个月内两组复发率比较,差异无统计学意义(P>0.05),随访3个月内电针组复发率明显低于西药组(P<0.05)。结论电针与益生菌合用黛力新均能有效治疗伴有焦虑和(或)抑郁的D-IBS,且在症状改善方面各有优势,但电针远期疗效较西药更好。
陈跃华陈兴奎尹小君施茵
关键词:腹泻型肠易激综合征电针疗法益生菌黛力新
Comparison of Electroacupuncture and Moxibustion on BrainGut Function in Patients with Diarrhea-Predominant Irritable Bowel Syndrome:A Randomized Controlled Trial被引量:21
2015年
Objective: To compare the effects of electroacupuncture (EA) and moxibustion therapies on patients with diarrhea-predominant irritable bowel syndrome (D-IBS). Methods: A total of 60 D-IBS patients were randomly allocated to the EA group (30 cases) and moxibustion group (30 cases). Before and after treatment, the gastrointestinal symptoms and psychological symptoms were scored by Visual Analogue Scale, Bristol Stool Form Scale, Hamilton Anxiety Rating Scale (HAMA), and Hamilton Depression Rating Scale (HAMD); the expressions of 5-hydroxytryptamine (5-HT), 5-HT3 receptor (5-HT3R), and 5-HT4 receptor (5-HT4R) in the sigmoid mucosal tissue were measured by immunohistochemical staining. Additionally, the effects on the functional brain areas of the anterior cingulate cortex (ACC), insular cortex (IC) and prefrontal cortex (PFC) were observed by functional magnetic resonance imaging. Results: Compared with before treatment, both EA and moxibustion groups reported significant improvements in abdominal pain and abdominal bloating after treatment (P〈0.01 or P〈0.05). The moxibustion group reported greater improvements in defecation emergency, defecation frequency, and stool feature than the EA group (P〈0.01). Both HAMA and HAMD scores were significantly decreased in the moxibustion group than in the EA group (P〈0.01). Both groups demonstrated significantly reduced expressions of 5-HT, 5-HT3R and 5-HT4R in the colonic mucosa after treatment (P〈0.01), with a greater reduction of 5-HT in the moxibustion group (P〈0.05). Finally, decreased activated voxel values were observed in the left IC, right IC and PFC brain regions of patients in the moxibustion group under stimulation with 150 mL colorectal distension after treatment (P〈0.05 or P〈0.01), while in the EA group only PFC area demonstrated a reduction (P〈0.05). Conclusion: Moxibustion can significantly improve the symptoms of D-IBS, suggesting that moxibustion may be a more
赵继梦卢金花尹小君陈兴奎陈跃华汤伟军金小明吴璐一包春辉吴焕淦施茵
关键词:DIARRHEAMOXIBUSTIONELECTROACUPUNCTURE
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