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中国科学院知识创新工程(KSCX2-EW-J-22)

作品数:5 被引量:25H指数:3
相关作者:郭坤张晟李帮经陈蓉陈浩东更多>>
相关机构:中国科学院成都生物研究所四川大学更多>>
发文基金:中国科学院知识创新工程国家自然科学基金中国科学院西部之光基金更多>>
相关领域:生物学理学医药卫生更多>>

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孔雀石绿和结晶紫在荧光检测中的比较被引量:5
2013年
为优选出三苯甲烷染料中的一种染料与G-四聚体结合开发为荧光定量报告体系,对孔雀石绿(Malachitegreen,MG)和结晶紫(Crystal violet,CV)与G-四聚体结合后的灵敏度和重现性进行了比较研究.首先,比较了4种不同DNA(hum21,short-hum21,double-strands,single-strand)分别与孔雀石绿和结晶紫结合后的荧光光谱,结果显示,两种染料均可区分以上4种DNA,但孔雀石绿的灵敏度更高.然后,将孔雀石绿和结晶紫应用到实时荧光检测中,进一步比较验证两种染料灵敏度,并考察两种染料的重现性,结果显示,孔雀石绿的重现性和灵敏度均优于结晶紫.由此,建立了孔雀石绿与G-四聚体结合的荧光定量报告体系.
赵永云杜凤董娟陈浩东周丽陈蓉唐卓
关键词:孔雀石绿结晶紫
导电自愈合材料的研究进展及应用被引量:3
2015年
高分子导电材料既具有金属的导电性又具有有机材料般的柔顺可加工性,在军事、能源、生物化学传感器等方面应用广泛。然而,其在制造使用过程中一旦发生破坏,就会造成电气元件的性能故障,甚至造成整个系统的瘫痪和报废。自愈合是人们模仿生物体损伤愈合的概念,解决材料损伤,延长材料使用寿命的新方法。本文综述了自愈合导电材料研究领域的最新动态,讨论了自愈合的机理和材料的制备方法,最后介绍了导电自愈合材料在超级电容器和电传感等方面的应用前景。我们相信导电自愈合材料的理论和应用研究会进一步推动电子器件领域的快速发展。
郭坤张大丽张晟李帮经
关键词:自愈合导电性复合材料
基于主客体识别的温度及氧化还原双重响应型磁性聚合物胶束
2015年
制备磁性纳米粒子和聚合物的复合材料是研究热点,而如何简单高效地构建磁性纳米粒子和聚合物的复合体系是目前研究的难点.基于此,本研究首先分别制备主体分子CD-MNPs和客体分子m PEG-Fc及PNIPAM-Fc,利用β-CD和二茂铁基团之间的主客体识别作用,在磁性纳米粒子表面构筑两种亲疏水性不同的聚合物链,通过控制温度的变化,使其在水中发生组装,同时通过氧化还原电位的变化,实现组装体系形成和瓦解的可逆变化.并对得到的胶束进行了载药性能的表征.TEM和DLS的结果显示得到了粒径大概为250 nm的磁性聚合物胶束,并可以通过温度和氧化还原的变化实现胶束的形成和瓦解,而且这种胶束可以作为药物载体,其对抗癌药物阿霉素(Dox)的包封率高达73%.综上,本研究得到了一种兼具温度和氧化还原敏感的磁性聚合物胶束,这种新型的胶束在药物释放和磁共振成像方面具有潜在的应用前景.
张晓梅郭坤张晟李帮经
关键词:磁性纳米粒子胶束药物载体
Endemic Amphibians and Their Distribution in China被引量:8
2012年
Amphibians are good indicators of ecosystem health. Updating the information of endemic species in time and understanding their spatial distributions are necessary for the development of integrative conservation strategies and the elucidation of geographic patterns of amphibians. We analyzed the diversity and distributions of the endemic amphibians in China based on a database of specimen records, recently published literature, and field surveys. Two hundred and sixty two endemic species of amphibians, belonging to 59 genera in 12 families and two orders, are recognized. They account for 67% of the total number of amphibian species in China, with the family Megophryidae possessing the largest number of endemics. There are also 17 genera endemic to China. Across provinces, the species richness of endemics shows five levels with a hierarchical diversification. Sichuan has the largest number of endemics, while Heilongjiang and Jilin have no endemic species. Alternatively, whether on the level of endemic genus or species, the highest diversity occurs in the Western Mountains and Plateau Subregion. The distribution ranges of most endemic species cover ≤ 4 provinces or zoogeographic subregions. Additionally, the species richness of endemics along an elevational gradient shows a bell-shaped pattern with the peak around 800 m. Most endemic species are distributed in areas of low to mid elevation(c. 700–1 500 m), while 36 species are distributed up to 3 000 m. Endemic species richness decreases with increasing of elevation range. Species at mid elevations display large range sizes, while species at lower and higher elevations exhibit smaller ranges. Our results are to be beneficial for further exploration of the underlying mechanisms of distributional patterns of amphibians in China. This study highlights a need to promote conservation programs for Chinese endemic amphibians due to their narrow distribution ranges and potential threats.
Junhua HUCheng LIFeng XIEJianping JIANG
关键词:CONSERVATION
A New Species of the Genus Feirana(Amphibia:Anura:Dicroglossidae) from the Western Qinling Mountains of China被引量:10
2011年
A new species, Feirana kangxianensis sp. nov., is described from the western Qinling Mountains in Gansu, China. Both morphological and molecular data support its validity. The new species is characterized by: (1) presence of keratinized nuptial spines on the thenar region of the hands in males of the new species, in contrast to F. taihangnica and F. quadranus; (2) of females, the ratios of UEW, INS, NSD and IPTL to SVL ofF. kangxianensis were significantly less than those of F. taihangnica and F. quadranus (P 〈 0.05), while the ratio of IOS to SVL of the new species was significantly larger than that of the latter two species (P 〈 0.05); and (3) of males, the ratios of INS, NSD, IPTW to SVL of the new species were significantly less than those ofF. taihangnica and F. quadranus (P 〈 0.05), while the ratio of HL to SVL of the former was significantly larger than that of the latter, and the ratio of HW to SVL ofF. kangxianensis was significantly larger than that of F. taihangnica but less than that of F. quadranus, the ratio of OPTL to SVL of F. kangxianensis was significantly less than that of F. taihangnica but larger than that of F. quadranus (P 〈 0.05). The three species of Feirana can be easily identified and significantly differ from each other by the canonical discriminant analyses with high correct classification (〉92%). Concurrently, based on partial mitochondrial ND2 gene sequences, the result of the molecular phylogenetic analyses of the Feirana indicates that the F. kangxianensis is sister to F. taihangnica.
Xin YANGBin WANGJunhua HUJianping JIANG
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