The isospin and density dependent effective pairing interaction is revisited by fitting the neutron gaps from the microscopic calculations for the neutron matter and the symmetric nuclear matter.The neutron pairing gaps for 1S0 channel for asymmetric nuclear matter are obtained from the BCS gap equation with a realistic bare nucleon-nucleon interaction in the Skyrme mean field.It is shown that the neutron gaps obtained from the new effective pairing interaction for the asymmetric nuclear matter are much improved and agree well with the microscopic results.