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国家自然科学基金(30873193)

作品数:4 被引量:30H指数:3
相关作者:杨云宋杰郭琦张鹏宵傅强更多>>
相关机构:西安交通大学更多>>
发文基金:国家自然科学基金更多>>
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Separation and enrichment of trace ractopamine in biological samples by uniformly-sized molecularly imprinted polymers被引量:4
2012年
In order to prepare a high capacity packing material for solid-phase extraction with specific recognition ability of trace ractopamine in biological samples, uniformly-sized, molecularly imprinted polymers (MIPs) were prepared by a multi-step swelling and polymerization method using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and toluene as a porogen respectively. Scanning electron microscope and specific surface area were employed to identify the characteristics of MIPs. Ultraviolet spectroscopy, Fourier transform infrared spectroscopy, Scatchard analysis and kinetic study were performed to interpret the specific recognition ability and the binding process of MIPs. The results showed that, compared with other reports, MIPs synthetized in this study showed high adsorption capacity besides specific recognition ability. The adsorption capacity of MIPs was 0.063 mmol/g at 1 mmol/L ractopamine concentra- tion with the distribution coefficient 1.70. The resulting MIPs could be used as solid-phase extraction materials for separation and enrichment of trace ractopamine in biological samples.
Ya LiQiang FuMeng LiuYuan-Yuan JiaoWei DuChong YuJing LiuChun ChangJian Lu
关键词:RACTOPAMINE
Applications of HPLC/MS in the analysis of traditional Chinese medicines被引量:17
2011年
In China, traditional Chinese medicines (TCMs) have been used in clinical applications for thousands of years. The successful hyphenation of high-performance liquid chromatography (HPLC) and mass spectrometry (MS) has been applied widely in TCMs and biological samples analysis. Undoubtedly, HPLC/MS technique has facilitated the understanding of the treatment mechanism of TCMs. We reviewed more than 350 published papers within the last 5 years on HPLC/MS in the analysis of TCMs. The present review focused on the applications of HPLC/MS in the component analysis, metabolites analysis, and pharmacokinetics of TCMs etc. 50% of the literature is related to the component analysis of TCMs, which show that this field is the most popular type of research. In the metabolites analysis, HPLC coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry has been demonstrated to be the powerful tool for the characterization of structural features and fragmentation behavior patterns. This paper presented a brief overview of the applications of HPLC/MS in the analysis of TCMs. HPLC/MS in the fingerprint analysis is reviewed elsewhere.
Miao Li Xiao- Fang Hou Jie Zhang Si-Cen Wang Qiang Fu Lang- Chong He
关键词:HPLC/MSPHARMACOKINETICS
Preparation and evaluation of monolithic molecularly imprinted stationary phase for S-naproxen被引量:2
2011年
An S-naproxen(S-NAP)molecularly imprinted monolithic stationary phase(MIMSP)with specific recognition for S-NAP and naproxen(NAP)was prepared by in situ technique,utilizing 4-vinylpridine(4-VP)as a function monomer,ethylene glycol dimethacrylate(EDMA)as a cross-linking agent,and low-polar solvents(toluene and dodecanol)as porogenic solvents.The selectivity of the polymers for S-NAP and NAP was evaluated by high performance liquid chromatography(HPLC).The binding characteristics were tested by Scatchard analysis.Racemic NAP could be specifically separated to some extent.At the same time,NAP could be separated from ibuprofen under optimized conditions.Scatchard analysis showed that two classes of binding sites existed in the S-NAP-imprinted polymers,with their dissociation constants estimated to be 1.045 and 5.496 μM,respectively.The results demonstrate that S-NAP and NAP can be recognized specifically on the obtained MIMSP.
De-Miao ChenQiang FuWei DuSi-Juan SunPing HuangChun Chang
关键词:NAPROXEN
GC法同时测定酚氨咖敏片中4种组分被引量:7
2010年
建立了同时测定酚氨咖敏片中对乙酰氨基酚、氨基比林、咖啡因和马来酸氯苯那敏4组分含量的毛细管气相色谱法。采用SE-30大口径毛细管色谱柱(30 m×0.53 mm,1.0μm),柱温190℃,汽化室温度220℃,检测器为FID,检测温度250℃,载气为高纯N2,分流比为1∶6,内标为盐酸麻黄碱,以无水乙醇为溶剂,样品无需衍生化处理,直接进样测定。样品中各组分完全分离,辅料无干扰,对乙酰氨基酚、氨基比林、咖啡因和马来酸氯苯那敏分别在20~2000μg/mL、15~1500μg/mL、10~500μg/mL和20~100μg/mL范围内线性关系良好(r>0.999),各组分的平均回收率在99.6%~101.2%范围内,RSD<2%。
郭琦傅强张鹏宵常春杨云宋杰
关键词:酚氨咖敏片对乙酰氨基酚氨基比林马来酸氯苯那敏毛细管气相色谱法
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