Aryl diketo acid derivatives are one of the most promising HIV-1 integrase（IN） inhibitors. With a view to substitute the critical diketo acid pharmacophore with the diketo benzimidazole unit, the coupling reaction of compound 4 with o-phenylenediamine was carried out. However, the reaction product, compound 5, was confirmed to be 3-{ [ 3- （phenylsulfonamido） benzoyl] methylidene t -3,4-dihydroquinoxaline-2 （1H） -one rather than the 2-benzimidazole derivative by using X-ray diffraction. Owing to its low solubility in water, the evaluation of the anti-HIV IN activity of the synthesized compound 5 could not be carried out. Consequently, the ion-binding properties of compound 5 in the absence of HIV-1 IN were investigated with UV-Vis spectroscopy in organic solvents. The results show that such a compound can selectively recognize Cu^2＋.
LI Xue-mei ZENG Cheng-chu NIU Li-ting YAN Hong ZHENG Da-wei ZHONG Ru-gang
