Endothelial lipase(EL),a newly described member of the triglyceride lipase gene family,displays a previously phospholipase A1 activity,remodels high density lipoprotein(HDL) particle and reduced plasma HDL-cholesterol levels and the ability to joint to scavenger receptor class B type 1(SR-B1).Furthermore,EL also increases cellular apolipoprotein B-containing lipoprotein uptake,monocyte adhesion and infiltration into the tissues.Recently,some studies showed that the vascular atherosclerotic lesions were markedly attenuated in EL deficient mice compared with control,suggesting that EL may play a significant role in the formation of atherosclerotic lesions.
