Supersonic extraction process of glycyrrhizia polysaccharide(GPS) was examined by orthogonal experiments . The optimized supersonic extraction process was obtained and mathematical simulation based on the supersonic extraction was established. The optimized condition for extraction of GPS is as follows: supersonic treatment time is 3 5 h, supersonic treatment temperature is 81 ℃, liquid solid ratio is 10 mL/g, number of times of extraction is 1. Under the optimized condition, the extraction rate of GPS is 5 40%, purity is 39 95% and the relative deviation of repeated experiments is 2 54%.
