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邓兆华

作品数:2 被引量:1H指数:1
供职机构:加州大学更多>>
相关领域:医药卫生更多>>

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脑:治疗SARS被忽略的器官
2004年
研究表明,糖皮质激素对BDNF的遗传因子会产生抑制作用。精神压力能够促进糖皮质激素的分泌,糖皮质激素抑制了BDNF的生成,海马体神经细胞在缺乏神经生长激素的滋润下萎缩,甚至死亡。
邓兆华Daiga Helmeste
关键词:SARS糖皮质激素传染病
Modulation of the suppressive effect of corticosterone on adult rat hippocampal cell proliferation by paroxetine被引量:1
2007年
Objective The literature has shown that cognitive and emotional changes may occur after chronic treatment with glucocorticoids. This might be caused by the suppressive effect of glucocorticoids on hippocampal neurogenesis and cell proliferation. Paroxetine, a selective serotonin reuptake transporter, is a commonly used antidepressant for alleviation of signs and symptoms of clinical depression. It was discovered to promote hippocampal neurogenesis in the past few years and we wanted to investigate its interaction with glucocorticoid in this study. Methods Adult rats were given vehicle, corticosterone, paroxetine, or both corticosterone and paroxetine for 14 d. Cell proliferation in the dentate gyrus was quantified using 5-bromo-2-deoxyuridine (BrdU) immunohistochemistry. Results The corticosterone treatment suppressed while paroxetine treatment increased hippocampal cell proliferation. More importantly, paroxetine treatment could reverse the suppressive effect of corticosterone on hippocampal cell proliferation. Conclusion This may have clinic application in preventing hippocampal damage after glucocorticoid treatment.
邱光Daiga M.HELMESTEAsanka N.SAMARANAYAKE刘汇文李湄珍邓兆华苏国辉
关键词:PAROXETINEBROMODEOXYURIDINECORTICOSTERONENEUROGENESIS
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