2型糖尿病是一种发病机制复杂,以胰岛素抵抗、β细胞数量减少与功能障碍为特征的疾病,糖尿病肾脏病(Diabetes Kidney Disease, DKD)是糖尿病常见的慢性并发症之一,是由糖尿病引起的慢性肾脏病(CKD)。近年来,一些研究表明,miRNA451a与胰岛素抵抗存在一定关系,在糖肾中发生表达的改变,影响糖肾的进展。本文综述了胰岛素抵抗和糖肾的发病机制与miRNA451a的关系,为更深入地了解miRNA51a对2型糖尿病及糖肾的发病机制及治疗提供参考。Type 2 diabetes is a complex disease characterized by insulin resistance, reduced β-cells and its dysfunction. Diabetic kidney disease (DKD) is one of the common chronic complications of diabetes and is chronic kidney disease (CKD) caused by diabetes. In recent years, several studies have shown that a certain relationship between miRNA451a and insulin resistance, and its altered expression occurs in DKD, affecting the progression of DKD. This review summarizes the relationship between insulin resistance and DKD with miRNA451a to provide a further understanding of the pathogenesis and treatment of miRNA51a in type 2 diabetes and DKD.
