[Objective] This study aimed to determine the optimal technical parameters for the swine wastewater treatment by struvite precipitation. [Method] Central composite design （CCD） and response surface method （RSM） were employed to study the effects of struvite precipitation on removing the ammonia nitrogen in the swine wastewater. Quadratic model was developed to describe the mathematical relationships between the investigated factors of pH value, reaction time, magnesium to nitrogen molar ratio （Mg/P）, nitrogen to phosphorus molar ratio （N/P）, the investigated indicators of NH 4 -N removal efficiency and residual PO 4 3 -P concentration. Contour overlay plot was proposed to predict the optimal experimental conditions with the NNH 4 -N removal efficiency of 75% and residual PO 4 3-P concentration of 3.0 mg/L as the desired values. [Result] At pH of 10.0, mixing time of 30 min, Mg/N of 1.11, N/P of 1.14, the NH 4 -N removal efficiency （Y 1 ） was the maximum of 79.0% , and the residual PO 4 3-P concentration （Y 2 ） at this time was 0.35 mg/L. The verification test of the optimal conditions proved that the verification data and model predictions agreed well. [Conclusion] The optimized parameters for the chemical struvite precipitation used to treat swine wastewater with central composite experimental design and response surface method are scientific, rational and efficient.
