A 78-year-old man got lumbago, edema for 9 years and cough, expectoration for 30 years, and was hospitalized with progressive severity of the symptoms for 5 days. He was diagnosed as coronary heart disease,chronic bronchitis, diabetes, and treated with anti-infection and symptomatic therapy. Several days later, he received allopurinol 100mg twice daily by mouth,because of high serum concentrations of uric acid. The patient developed chill, hyperpyrexia and fatigue after 9 consecutive days of administration. Physical examination revealed a temperature of 39.6℃ and lab findings included WBC 0.8×109/L with neutrophil 0.4. Aplastic anemia was approved on bone marrow puncture. Allopurinol was withdrawn immediately and the the symptoms were resolved.
