Chemical examination of an unidentified sponge associated marine fungus Penicillium terrestre resulted in the isolation of eight compounds. Their structures are identified as cyclo （glycyl-D-proline） （1）, cyclo （L-prolyl-L-alanine） （2）, cyclo （L-prolyl- D-alanine） （3）, cyclo （L-leucyl-trans-4-hydroxy-L-proline） （4）, cyclo （L-leucyl-cis-4-hydroxy-D-proline） （5）, cyclo （L-trans-（4- hydroxyprolinyl）-L-phenylalanine） （6）, hexylitaconic acid （7）, and hexylitaconic methylate （8）, based on spectroscopic analysis （1D, 2D NMR）. Compounds 7, 8 were obtained from the genus Penicillium for the first time, while compounds 1-6 were isolated from the fungus Penicillium terrestre for the first time.
乙型肝炎病毒(hepatitis B virus,HBV)感染可引起急性和慢性乙型肝炎,其中慢性感染是肝硬化和肝癌的主要致病因素[1]。我国是HBV感染的中高度流行区,有约8000万HBV慢性感染者,其中慢性乙型肝炎患者约2000万,是影响国人健康的重大传染病之一。尽管现有的抗病毒药物已能很好地抑制病毒复制。
