乳腺癌现已跃居全球恶性肿瘤榜首。在乳腺癌的治疗中,虽然现在已经有靶向治疗、内分泌治疗、免疫治疗等多种治疗方式,但化疗作为最经典的治疗方式仍发挥不可或缺的作用。然而其不良反应大、作用不持久、肿瘤间歇期重修复和易耐药等缺点,限制了其临床应用。节拍化疗是随之衍生而来的一种新的治疗方式,采用低量、高频、持续给药方式,通过直接杀死癌细胞、抗肿瘤血管生成、抗癌免疫应答的激活等机制发挥抗肿瘤的作用,进而延缓肿瘤的进展及转移。现对节拍化疗在乳腺癌中应用及研究进展综述如下。Breast cancer has ranked the top of the global malignant tumors. In the treatment of breast cancer, although targeted therapy, endocrine therapy, immunotherapy and other treatments are available, chemotherapy as the most classical treatment still plays an indispensable role. However, its clinical application is limited due to serious adverse reactions, unsustainable effect, intermittent repair and easy drug resistance. Metronomic chemotherapy is a new therapeutic method derived from it, which adopts low-dose, high frequency continuous administration to play an anti-tumor role by direct tumor cell death, antiangiogenic and activation of the anticancer immune response, so as to delay tumor progression and metastasis. The application and research progress of metronomic chemotherapy in breast cancer are reviewed as follows.
