ABSTRACT Objective To compare the efficacy difference between point injection at Jiiaji (夹脊 EX-B 2) and oral medication in the treatment of intractable post-herpetic neuralgia (PHN) in the trunk. Methods One hundred and thirty cases were randomly divided into an point injection group and an medication group, 65 cases in each one. In point injection group, according to the invasion site of herpes zoster, Jiiaji (夹脊 EX-B 2) of corresponding segments and the meridian points on skin lesion areas, such as Fengchi (风池GB 20), Tianzhu (天柱 BL 10), Feishu (肺俞 BL 13) and Geguan (膈关 BL 46) were selected and injected with the mixed solution of compound Betamethasone (administered only in the first injection), Vitamin B12 and Lidoeaine Carbonate, 2 mL on each point, once per day. In medication group, Diclofenac Sodium sustained release tablets, 75 mg were administered, twice per day. The clinical efficacy was compared 10 days later between two groups. Results The total effective rate in point injection group was 100.0% (65/65), which was better than 66.1% (43/65) in medication group (P〈0.01). Conclusion Point injection mainly at Jiiaji (夹脊 EX-B 2) is effective significantly on intractable PHN in the trunk, which is superior to Diclofenac Sodium sustained release tablets.