2-Aryl-3,5,5-trimethyl-2-morpholinols were synthesized from the reactions o f 2-methyl-2-aminopropanol with 2-bromopropiophenone, 2-bromo-3′-chlorop ropiophenone, 2-bromo-4′-benzyloxypropio-phenone or 6-methoxy-2-（2- bromopropionyl）naphthalene for 1 h in N-methylpyrrolidone at 35 ℃. The 2 -aryl-3,5,5-trimethyl-2-morpholinols were then reacted with hydrochlo ride in Et2O to give the corresponding hydrochloride salts with yields of 84.9%86.4%, respectively. The structures of 2-aryl-3,5,5-trimethyl-2-mor pholinol hydrochlorides were confirmed by mean of IR, 1H NMR, MS spectral data.
