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张建达

作品数:5 被引量:16H指数:2
供职机构:南开大学更多>>
发文基金:国家重点基础研究发展计划国家教育部博士点基金国家自然科学基金更多>>
相关领域:医药卫生生物学化学工程更多>>

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尿毒症中分子毒物的分离鉴定
2005年
Sera and urine from patients with severe uremia and healthy persons were separated by means of gel permeation chromatography on Sephadex G-15 column with N(C2H5)3-H2CO3 buffer as the eluent. Two middle molecular peaks(A and B) were detected at 206 nm in normal urine, uremic serum and uremic urine, but these two peaks were hardly observed in the profile of normal sera. In contrast, the absorption at 206 nm of fractions A and B from uremic urine were smaller than that of fractions A and B from normal urine. Fractions A from normal urine, uremic serum and urine were collected and resolved into 3 subpeaks at 254 nm by high performance liquid chromatography. Two of these subpeaks, A-Ⅰ and A-Ⅱ, were detected in uremic serum, normal urine and uremic urine. The results of MALDI-TOF-MS revealed that the fraction A-Ⅰ from both uremic serum and normal urine contained a component with molecular weight {1 214}, which could hardly be seen in the fraction A-Ⅰ of uremic urine.
杨眉张建达王芃刘晓航袁直刘宏富杨洪涛杨淑芬赵菁丽
关键词:尿毒症中分子高效液相色谱飞行时间质谱
多肽吸附剂的合成及其与多肽识别机理的研究
中分子肽类物质被认为是尿毒症毒素的重要组成部分,对其吸附剂的研究具有很强的应用前景。研究具有高选择性的中分子吸附剂即成为血液灌流疗法中一项迫切需要解决的课题。 本组前期工作中从尿毒症患者血清中通过分级分离检测得...
张建达
关键词:分子识别二维核磁共振血液灌流疗法
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慢性肾衰患者血清中分子物质浓度变化及其对Na,K-ATP酶的抑制作用被引量:2
2005年
Sera from patients with different courses of chronic renal failure and healthy persons were separated by gel permeation chromatography,and the concentration of middle molecular fraction B were calculated.The concentration of fractions B was increasing with the aggravating of renal failure degree,which indicated that the concentration of fraction B was related to patients′ renal failure.Fractions B from uremic urine,uremic sera or normal urine were resolved into 10 to 17 sub-fractions by ion exchange chromatography.Sub-fractions from normal urine and from uremic sera were assayed for their inhibition for the activity of Na,K-ATPase.The results showed that the Na,K-ATPase activities of the samples with B-8 and B-9 were much lower than that of blank.It is indicated that B-8 and B-9 contained some compounds which could inhibit the activity of Na,K-ATPase.
杨眉储结根张建达袁直杨洪涛刘宏富赵菁丽杨淑芬
关键词:慢性肾衰中分子
尿毒症中分子毒物的分离鉴定
目的:对尿毒症患者及正常人的血清和尿样进行凝胶色谱.高效液相色谱-飞行时间质谱分析,发现正常人尿样和患者血清中均含有大量的分子量为1214的前人未见报道的新物质,而患者尿样中只有极少量.因而推测分子量为1214的物质可能...
杨眉张建达王芃刘晓航袁直刘宏富杨洪涛杨淑芬赵菁莉
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血液灌流材料研究进展被引量:14
2006年
血液灌流技术以其显著的疗效和新颖的治疗方法而发展迅速,目前其应用正日趋广泛,所治疗的疾病已经从药物中毒、肝肾疾病扩展到一系列免疫性疾病。本文综述了血液灌流材料的发展和研究进展,按照种类不同对材料的性质和应用进行了阐述,为血液灌流材料的制备和应用提供参考。
张建达袁直
关键词:血液灌流
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