植入式医疗器件(Implanted Medical Device)是出于医学诊断或治疗目的而”长期”植入人体内的装置或器件，其体积较小，与生物组织相容性好，有特殊的功能。近年来，有关植入式医疗器件的研究发展迅速，已成为当前生物医学工程领域的研究热点，其中植入式芯片系统(Implanted Chip System)更是该领域最活跃的前沿课题。植入式芯片系统的核心是微处理芯片，
Objective: To evaluate the efficiency of an implanted chip system on blood pressure regulation. Methods: The mean arterial pressure (MAP) and heart rate (HR) were recorded in anesthetized rabbits. Based on the set point theory, an implanted chip system was designed to regulate the blood pressure by stimulating the aortic depressor nerve (ADN) according to the feedback of blood pressure. The blood pressure regulation induced by the implanted chip system was carried out twice (lasted for 15 min and 60 min respectively) and the change of MAP and HR during the regulation was compared with the control. Results: There was a significant decrease of MAP during the first regulation ([-32.0 ± 6.6] mmHg) and second regulation ([-27.4 ± 6.2] mmHg) compared with the control (P<0.01). The HR was also significantly decreased during regulation compared with the control. Both MAP and HR returned to the baseline immediately without rebound after the regulation ceased. Conclusion: The implanted chip system can regulate the blood pressure successfully and keep the blood pressure in a lower constant level without adaptation.
