抑郁症是一类高致残率且难治愈的精神类疾病,目前其临床诊断和治疗都面临很大的困难,因此研究抑郁症患病机制,寻找抑郁症的潜在治疗靶点,并开发有效临床治疗手段刻不容缓。沉默信息调节因子2同源体1 (silent mating type information regulator 2 homolog 1, SIRT1)作为一种去乙酰化酶,参与细胞衰老、癌症、心血管疾病等多种生物学过程。近年来,越来越多的研究发现SIRT1基因在抑郁症发病过程中发挥了重要的作用,但是其机制尚不明确。本文主要总结了海马、前额叶皮层、杏仁核、下丘脑视交叉上核脑区和伏隔核中SIRT1基因影响抑郁症病理过程的相关研究进展,以期为抑郁症机制研究和抗抑郁药物的研发提供一定的参考和帮助。
临床实习在高层次医学人才培养的过程中至关重要,近年来各医学院校在临床实习模式上不断进行探索改革。作为综合性大学中新办医学院,在建立临床实习教学模式的过程中也面临诸多挑战,如医校双方监管制度不完善、临床师资学科背景单一、教学水平有局限性、教学方法过于陈旧等问题。为建立适应“新医科”发展需求的临床实习模式,通过健全临床实习管理体系,打造高水平、跨学科师资教学团队,推进各实习医院教学同质化,采用新型教学方法,结合现代医学发展需求及学校特色,增加医工融合的实训实践比例等方法,在综合性大学医学院中建立“一核两翼三化四全”的临床实习模式,旨在培养具有岗位胜任力的复合型、国际化、高层次临床医学人才。Clinical internship is vitally important in the cultivation of high-level medical talents. In recent years, medical colleges have been constantly exploring and reforming the clinical internship model. As a newly established medical school in the comprehensive university, it faces many challenges in establishing a clinical internship teaching model, such as incomplete supervision systems in both the medical school and hospital, single disciplinary backgrounds of clinical teachers, limited teaching levels, and outdated teaching methods. To establish a clinical internship model that meets the development needs of “new medical science”, methods such as improving the clinical internship management system, building a high-level and cross-disciplinary teaching team, promoting teaching homogenization in different internship hospitals, adopting new teaching methods, and increasing the proportion of medical-engineering integration practical training in line with modern medical development needs and school characteristics are adopted. A clinical internship model of “one core, two wings, three paths, and four contains” is established in the medical school of the compr
