目的：探讨胎儿生长受限与脐血流比值及孕妇红细胞压积的关系。方法选取广州医学院附属深圳沙井人民医院2009年1月至2013年8月诊治的胎儿生长受限孕妇73例为观察组，选取本院同期正常孕妇74例为对照组，均行脐血流比值及孕妇红细胞压积检测，分析两组孕妇的孕期合并症，比较两组孕妇及胎儿的妊娠结局，分析胎儿生长受限与脐血流比值及孕妇红细胞压积的相关性。结果随着孕周的增加，脐血流比值呈现出降低的趋势，但观察组孕妇胎儿脐血流比值在32～42周均明显高于对照组；观察组孕妇妊娠期糖尿病、妊娠期高血压疾病、产后出血、泌尿系统感染、胎盘早剥发生率及剖宫产率明显高于对照组（P 〈0.05）；观察组早产、胎儿窘迫、新生儿低体重及新生儿窒息发生率均明显高于对照组（ P 〈0.05），胎儿生长受限与脐血流比值、孕妇红细胞压积呈明显的正相关性（P 〈0.05）。结论胎儿生长受限与脐血流比值及孕妇红细胞压积关系密切，血液浓缩与脐血流阻力增加会进一步加剧胎儿生长受限，会直接影响到孕妇及胎儿的妊娠结局。
Objective To explore the relationship between heat-shock protein 70-2 gene +1267A/G polymorphism(HSP70-2 gene +1267A/G polymorphism) and serum level of high sensitivity C-reactive protein(Hs-CRP) in patients with coronary artery disease(CAD).Methods Serum Hs-CRP level and HSP70-2 gene +1267A/G polymorphism were detected in 185 patients with CAD.HSP70-2 gene +1267A/G polymorphism was screened by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results The genotype distribution of the HSP70-2 gene +1267A/G polymorphism was as follows: AA was in 24 of 185 patients(12.97%),AG in 93 of 185 patients(50.27%) and GG in 68 of 185 patients(36.76%).Patients with GG、AG subtype had higher Hs-CRP levels compared with carriers of the AA subtype(4.5±1.8mg/L,3.2±1.2mg/L and 2.7±1.1mg/L,respectively,P<0.05).Among patients who had Hs-CRP >3mg/L,GG,and AG gene subtypes had higher percentage than A allele homozygotes(92.6%,74.2% and 45.8%,respectively.χ2=17.75,28.04,P<0.05).Conclusions This study indicated G allele of HSP70-2 gene +1267A/G polymorphism may be an independent risk factor in systemic inflammation with stable CAD.
