Objective To explore the effect of moxibustion at ＂Shénquè＂（神阙 CV 8） on the immune system of rats taking long-term exhaustive exercise.Method Thirty male SD rats were randomly divided into blank group,model group and moxibustion group with 10 rats in each group.Except the rats in blank group,all the rats were established into long-term exhaustive models through swimming again and again.Mild moxibustion at CV 8 for 15 min was carried out in the rats in moxibustion group after modeling.The treatment was conducted once every other day,and treatment for 10 times was needed.The exhaustive duration for each time was recorded,the levels of serum Ig A,Ig G,Ig M and ACP were detected 24 h after the 10 th exhaustive exercise,and the histomorphological changes of spleen were observed.Immunoturbidimetry was adopted for detecting the Ig A level,and ELISA method was used for detecting the levels of Ig G,Ig M and ACP.Results The common exhaustive duration in moxibustion group was longer than that in model group,however,the time difference was statistically significant after the 5th exhaustive exercise（P0.01）.The levels of serum IgG and IgM in model group were lower than that in blank group（all P0.01）,and the serum ACP level in model group was higher than that in blank group（P0.01）,indicating that the splenic histomorphology was damaged.The levels of serum Ig G and Ig M in moxibustion group were higher than that in model group（all P0.01）,and the serum ACP level in moxibustion group was lower than that in model group,showing that the splenic histomorphology was repaired.Conclusion Moxibustion at CV 8 can improve the levels of immunoglobulin（Ig G,Ig A,Ig M） of tired body for a long time,decrease the ACP level,and repair the damaged spleen tissues.
目的研究基于大数据的中药注射剂不良反应自动监测的方法。方法选取河北省中医院2018年至2020年药物不良反应(adverse drug reaction,ADR)报道率最高的5种中药注射剂,基于中国知网数据库中相关ADR大数据筛选报道最多ADR,选择其中可通过计算机手段进行监测的5类ADR生成ADR风险监测信号,设置监测规则,利用ADR自动监测软件对2021年我院中药注射剂进行实时ADR风险监测;以报告比数比(reporting odds ratio,ROR)法为风险信号评价方法,95%CI下限>1为有效风险信号产生条件进行风险数据挖掘。结果ADR风险信号监测结果显示:参麦注射液在恶心呕吐、肾损害和白细胞减少三个不良反应上的95%CI下限大于1。挖掘到“喜炎平注射液致恶心呕吐”、“参麦注射液致肾损害”、“参麦注射液致白细胞减少”三个有效风险信号。其中喜炎平注射液致恶心呕吐217例,参麦注射液致白细胞减少14例,参麦注射液致肾损害5例。结论中药注射剂ADR监测中应用基于大数据的ADR自动监测,可实现实时主动监测,提升工作效率,减少误报率,提升临床用药风险防范及管控能力。
