Inductively coupled plasma mass spectrometry (ICP-MS) was applied to determine copper, arsenic, cadmium, lead in athletic food using Sc, Ge, In, Bi as an internal standard. The linear correlation factor for four elements are higher than 0.999. Recoveries of spiked samples are in the range of 85.5%-115.5% and precision was fine, RSD is lower than 5.0%. And these are close agreement with the reference values in three standard reference materials of GBW08503, NBS1568, GBW08571. It indicates that the method is simple, rapid, sensitive and accurate, which can meet the demand for copper, arsenic, cadmium, lead analysis in athletic food.