2acetylamino3,4,6triacetate Dglucopyranose is an important imtermediate in the synthesis of Lipid A analogs.It was synthesized by the regioselective 1Odeacylation of fully acylated sugars.In this paper, the fully acylated aminoglucose was synthesized by a new method.In comparison with the old procedure,the reaction time was shorten ed,yet the yield was still higher.
Thin layer chromatography was used to separate and analyze the samples in the process of preparation of β d glucopyranose 1 bromo 2 amino 2,3,4,6 tetra acetyl ester.The best developing solvent system is ethyl acetate∶methane alcohol∶water=6∶3∶0.5(V/V).The reactants, inter mediates and products could be separated effectively,thus indicated the reaction progression obviously.
